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Gene: SBDS (SBDS ribosome maturation factor) Homo sapiens
Symbol: SBDS
Name: SBDS ribosome maturation factor
Description: This gene encodes a highly conserved protein that plays an essential role in ribosome biogenesis. The encoded protein interacts with elongation factor-like GTPase 1 to disassociate eukaryotic initiation factor 6 from the late cytoplasmic pre-60S ribosomal subunit allowing assembly of the 80S subunit. Mutations within this gene are associated with the autosomal recessive disorder Shwachman-Bodian-Diamond syndrome. This gene has a closely linked pseudogene that is distally located. [provided by RefSeq, Jan 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CGI-97; FLJ10917; ribosome maturation protein SBDS; SBDS ribosome assembly guanine nucleotide exchange factor; SBDS, ribosome assembly guanine nucleotide exchange factor; SBDS, ribosome maturation factor; SDS; Shwachman-Bodian-Diamond syndrome; SWDS
Mus musculus (house mouse) : Sbds (SBDS ribosome maturation factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sbds (SBDS, ribosome maturation factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sbds (SBDS ribosome maturation factor)
Pan paniscus (bonobo/pygmy chimpanzee) : SBDS (SBDS ribosome maturation factor)
Canis lupus familiaris (dog) : SBDS (SBDS ribosome maturation factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sbds (SBDS ribosome maturation factor)
Sus scrofa (pig) : SBDS (SBDS ribosome maturation factor)
more info ...
Related Pseudogenes: SBDSP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38766,987,677 - 66,995,696 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37766,452,690 - 66,460,588 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36766,090,125 - 66,098,023 (-)NCBINCBI36hg18NCBI36
Build 34765,896,839 - 65,904,738NCBI
Celera765,655,621 - 65,663,519 (+)NCBI
Cytogenetic Map7q11.21NCBI
HuRef762,635,769 - 62,643,913 (-)NCBIHuRef
CHM1_1766,547,913 - 66,555,811 (-)NCBICHM1_1
CRA_TCAGchr7v2765,790,252 - 65,798,150 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SBDS
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322290
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.