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Gene: Tirap (toll-interleukin 1 receptor (TIR) domain-containing adaptor protein) Mus musculus
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Symbol: Tirap
Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
Description: Exhibits Toll-like receptor 2 binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein dimerization activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of cytokine production; and response to bacterium. Localizes to the endocytic vesicle and ruffle membrane. Human ortholog(s) of this gene implicated in malaria; primary immunodeficiency disease; and tuberculosis. Is expressed in testis. Orthologous to human TIRAP (TIR domain containing adaptor protein); PARTICIPATES IN Toll-like receptor signaling pathway; tuberculosis pathway; INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA407980; adaptor protein Wyatt; C130027E04Rik; Mal; myD88 adapter-like protein; MyD88-adapter-like; TIR domain-containing adapter protein; Tlr4ap; Toll-like receptor 4 adaptor protein; toll/interleukin-1 receptor domain-containing adapter protein; Wyatt
Orthologs:
Homo sapiens (human) : TIRAP (TIR domain containing adaptor protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tirap (TIR domain containing adaptor protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tirap (TIR domain containing adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TIRAP (TIR domain containing adaptor protein)
Canis lupus familiaris (dog) : TIRAP (TIR domain containing adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tirap (TIR domain containing adaptor protein)
Sus scrofa (pig) : TIRAP (TIR domain containing adaptor protein)
Chlorocebus sabaeus (African green monkey) : TIRAP (TIR domain containing adaptor protein)
Heterocephalus glaber (naked mole-rat) : Tirap (TIR domain containing adaptor protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl935,184,551 - 35,200,291 (-)EnsemblGRCm38mm10GRCm38
GRCm38935,184,391 - 35,200,291 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37934,991,976 - 35,007,876 (-)NCBIGRCm37mm9NCBIm37
MGSCv36934,936,435 - 34,949,545 (-)NCBImm8
Celera932,421,410 - 32,437,270 (-)NCBICelera
Cytogenetic Map9A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tirap
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322403
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.