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Gene: Tirap (toll-interleukin 1 receptor (TIR) domain-containing adaptor protein) Mus musculus
Symbol: Tirap
Name: toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
Description: Exhibits Toll-like receptor 2 binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein dimerization activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of cytokine production; and response to bacterium. Localizes to the endocytic vesicle and ruffle membrane. Human ortholog(s) of this gene implicated in malaria; primary immunodeficiency disease; and tuberculosis. Is expressed in testis. Orthologous to human TIRAP (TIR domain containing adaptor protein); PARTICIPATES IN Toll-like receptor signaling pathway; tuberculosis pathway; INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA407980; adaptor protein Wyatt; C130027E04Rik; Mal; myD88 adapter-like protein; MyD88-adapter-like; TIR domain-containing adapter protein; Tlr4ap; Toll-like receptor 4 adaptor protein; toll/interleukin-1 receptor domain-containing adapter protein; Wyatt
Homo sapiens (human) : TIRAP (TIR domain containing adaptor protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tirap (TIR domain containing adaptor protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tirap (TIR domain containing adaptor protein)
Pan paniscus (bonobo/pygmy chimpanzee) : TIRAP (TIR domain containing adaptor protein)
Canis lupus familiaris (dog) : TIRAP (TIR domain containing adaptor protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tirap (TIR domain containing adaptor protein)
Sus scrofa (pig) : TIRAP (TIR domain containing adaptor protein)
Chlorocebus sabaeus (African green monkey) : TIRAP (TIR domain containing adaptor protein)
Heterocephalus glaber (naked mole-rat) : Tirap (TIR domain containing adaptor protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl935,184,551 - 35,200,291 (-)EnsemblGRCm38mm10GRCm38
GRCm38935,184,391 - 35,200,291 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37934,991,976 - 35,007,876 (-)NCBIGRCm37mm9NCBIm37
MGSCv36934,936,435 - 34,949,545 (-)NCBImm8
Celera932,421,410 - 32,437,270 (-)NCBICelera
Cytogenetic Map9A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tirap
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322403
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.