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Gene: Aire (autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)) Mus musculus
Symbol: Aire
Name: autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
CRRD ID: 1322441
Description: Exhibits identical protein binding activity. Involved in several processes, including immune system development; positive regulation of transcription by RNA polymerase II; and regulation of thymocyte migration. Localizes to cytoplasm and nuclear body. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study Guillain-Barre syndrome; Sjogren's syndrome; and autoimmune polyendocrine syndrome type 1. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator); PARTICIPATES IN primary immunodeficiency pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,2-dichloroethane; D-mannitol; menadione.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: APECED protein homolog; autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog; autoimmune regulator; autoimmune regulator AIRE1a; MGC123374; MGC123375
Homo sapiens (human) : AIRE (autoimmune regulator)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Aire (autoimmune regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aire (autoimmune regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : AIRE (autoimmune regulator)
Canis lupus familiaris (dog) : AIRE (autoimmune regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aire (autoimmune regulator)
Sus scrofa (pig) : AIRE (autoimmune regulator)
Chlorocebus sabaeus (African green monkey) : AIRE (autoimmune regulator)
Heterocephalus glaber (naked mole-rat) : Aire (autoimmune regulator)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391077,865,856 - 77,879,444 (-)NCBI
GRCm381078,030,022 - 78,043,610 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1078,030,022 - 78,043,610 (-)EnsemblGRCm38mm10GRCm38
MGSCv371077,492,776 - 77,506,325 (-)NCBIGRCm37mm9NCBIm37
MGSCv361077,433,160 - 77,446,709 (-)NCBImm8
Celera1079,069,034 - 79,082,580 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Aire
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322441
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-10-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.