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Gene: PRKG1 (protein kinase cGMP-dependent 1) Homo sapiens
Symbol: PRKG1
Name: protein kinase cGMP-dependent 1
CRRD ID: 1322442
Description: Exhibits cGMP-dependent protein kinase activity; calcium channel regulator activity; and identical protein binding activity. Involved in several processes, including negative regulation of platelet aggregation; negative regulation of vascular associated smooth muscle cell migration; and negative regulation of vascular smooth muscle cell proliferation. Localizes to cytoplasm and plasma membrane. Implicated in thoracic aortic aneurysm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1; AAT8; cGK; cGK 1; cGK1; CGKI; cGKI-alpha; cGKI-BETA; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; DKFZp686K042; FLJ36117; MGC71944; PGK; PKG; PKG1; PRKG1B; PRKGR1B; protein kinase, cGMP-dependent, regulatory, type I, beta
Mus musculus (house mouse) : Prkg1 (protein kinase, cGMP-dependent, type I)  MGI  Alliance
Rattus norvegicus (Norway rat) : Prkg1 (protein kinase cGMP-dependent 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prkg1 (protein kinase cGMP-dependent 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PRKG1 (protein kinase cGMP-dependent 1)
Canis lupus familiaris (dog) : PRKG1 (protein kinase cGMP-dependent 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prkg1 (protein kinase cGMP-dependent 1)
Sus scrofa (pig) : PRKG1 (protein kinase cGMP-dependent 1)
Chlorocebus sabaeus (African green monkey) : PRKG1 (protein kinase cGMP-dependent 1)
Heterocephalus glaber (naked mole-rat) : Prkg1 (protein kinase cGMP-dependent 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1050,990,888 - 52,298,423 (+)EnsemblGRCh38hg38GRCh38
GRCh381050,990,888 - 52,298,350 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371052,750,911 - 54,058,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361052,420,951 - 53,725,280 (+)NCBINCBI36hg18NCBI36
Build 341052,504,298 - 53,725,280NCBI
Celera1046,013,603 - 47,318,321 (+)NCBI
Cytogenetic Map10q11.23-q21.1NCBI
HuRef1046,729,527 - 48,036,312 (+)NCBIHuRef
CHM1_11053,032,644 - 54,339,928 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRKG1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322442
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.