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Gene: KDM5B (lysine demethylase 5B) Homo sapiens
Symbol: KDM5B
Name: lysine demethylase 5B
CRRD ID: 1322449
Description: Exhibits several functions, including histone demethylase activity (H3-K4 specific); transcription corepressor activity; and zinc ion binding activity. Involved in histone H3-K4 demethylation. Localizes to cytosol and nucleoplasm. Implicated in autosomal recessive non-syndromic intellectual disability; breast cancer; and malignant glioma. Biomarker of esophagus squamous cell carcinoma; malignant glioma; prostate cancer; urinary bladder cancer; and uveal melanoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: [histone H3]-trimethyl-L-lysine(4) demethylase 5B; cancer/testis antigen 31; CT31; FLJ10538; FLJ12459; FLJ12491; FLJ16281; FLJ23670; histone demethylase JARID1B; JARID1B; jumonji, AT rich interactive domain 1B; jumonji, at rich interactive domain 1b (rbp2-like); jumonji/ARID domain-containing protein 1B; lysine (K)-specific demethylase 5B; lysine-specific demethylase 5B; MRT65; PLU-1; PLU1; PPP1R98; PUT1; putative DNA/chromatin binding motif; RBBP2H1A; RBP2-H1; RBP2-like; retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A
Mus musculus (house mouse) : Kdm5b (lysine (K)-specific demethylase 5B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kdm5b (lysine demethylase 5B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kdm5b (lysine demethylase 5B)
Pan paniscus (bonobo/pygmy chimpanzee) : KDM5B (lysine demethylase 5B)
Canis lupus familiaris (dog) : KDM5B (lysine demethylase 5B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kdm5b (lysine demethylase 5B)
Sus scrofa (pig) : KDM5B (lysine demethylase 5B)
Chlorocebus sabaeus (African green monkey) : KDM5B (lysine demethylase 5B)
Heterocephalus glaber (naked mole-rat) : Kdm5b (lysine demethylase 5B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1202,724,495 - 202,808,487 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1202,724,495 - 202,809,470 (-)EnsemblGRCh38hg38GRCh38
GRCh381202,724,495 - 202,809,470 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371202,696,532 - 202,777,549 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,963,155 - 201,044,172 (-)NCBINCBI36hg18NCBI36
Build 341199,428,188 - 199,509,206NCBI
Celera1175,824,418 - 175,906,769 (-)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1173,862,355 - 173,943,136 (-)NCBIHuRef
CHM1_11204,116,533 - 204,200,837 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KDM5B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322449
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.