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Gene: ZIC2 (Zic family member 2) Homo sapiens
Symbol: ZIC2
Name: Zic family member 2
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Predicted to be involved in central nervous system development; regulation of transcription, DNA-templated; and visual perception. Localizes to the nuclear body. Implicated in holoprosencephaly and holoprosencephaly 5.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HPE5; Zic family member 2 (odd-paired Drosophila homolog); Zic family member 2 (odd-paired homolog, Drosophila); Zinc finger protein of the cerebellum 2; zinc finger protein ZIC 2
Mus musculus (house mouse) : Zic2 (zinc finger protein of the cerebellum 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Zic2 (Zic family member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Zic2 (Zic family member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ZIC2 (Zic family member 2)
Canis lupus familiaris (dog) : ZIC2 (Zic family member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Zic2 (Zic family member 2)
Sus scrofa (pig) : ZIC2 (Zic family member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381399,981,784 - 99,986,765 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713100,634,026 - 100,639,019 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361399,432,320 - 99,437,020 (+)NCBINCBI36hg18NCBI36
Build 341399,432,319 - 99,437,019NCBI
Celera1381,478,855 - 81,483,555 (+)NCBI
Cytogenetic Map13q32.3NCBI
HuRef1381,227,505 - 81,232,531 (+)NCBIHuRef
CHM1_113100,603,892 - 100,608,865 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ZIC2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322491
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.