Gdf7 (growth differentiation factor 7) - Chinchilla Research Resource Database
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Gene: Gdf7 (growth differentiation factor 7) Mus musculus
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Symbol: Gdf7
Name: growth differentiation factor 7
CRRD ID: 1322501
Description: Exhibits identical protein binding activity. Involved in several processes, including morphogenesis of an epithelium; nervous system development; and positive regulation of tendon cell differentiation. Localizes to extracellular region. Is expressed in several structures, including hindbrain; limb; and metanephros. Orthologous to human GDF7 (growth differentiation factor 7).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BMP1; BMP12; GDF-7; growth/differentiation factor 7
Orthologs:
Homo sapiens (human) : GDF7 (growth differentiation factor 7)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gdf7 (growth differentiation factor 7)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gdf7 (growth differentiation factor 7)
Pan paniscus (bonobo/pygmy chimpanzee) : GDF7 (growth differentiation factor 7)
Canis lupus familiaris (dog) : GDF7 (growth differentiation factor 7)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gdf7 (growth differentiation factor 7)
Sus scrofa (pig) : GDF7 (growth differentiation factor 7)
Chlorocebus sabaeus (African green monkey) : GDF7 (growth differentiation factor 7)
Heterocephalus glaber (naked mole-rat) : Gdf7 (growth differentiation factor 7)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39128,347,918 - 8,351,954 (-)NCBI
GRCm38128,297,918 - 8,301,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl128,297,918 - 8,301,954 (-)EnsemblGRCm38mm10GRCm38
MGSCv37128,304,724 - 8,308,760 (-)NCBIGRCm37mm9NCBIm37
MGSCv36128,323,926 - 8,327,962 (-)NCBImm8
Celera128,691,764 - 8,695,838 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:8145850   PMID:9786991   PMID:9808626   PMID:10022976   PMID:10516314   PMID:10693795   PMID:10952903   PMID:11238730   PMID:11356021   PMID:11356025   PMID:11395003   PMID:11877374  
PMID:12606286   PMID:12639970   PMID:12741987   PMID:15105374   PMID:15183721   PMID:15342483   PMID:15691760   PMID:15883363   PMID:15975937   PMID:16049014   PMID:16364898   PMID:16602821  
PMID:16753809   PMID:16790481   PMID:16855091   PMID:17150208   PMID:17728348   PMID:18240333   PMID:18302280   PMID:18429041   PMID:18480159   PMID:18590716   PMID:19570847   PMID:19668217  
PMID:19741143   PMID:19815519   PMID:20123094   PMID:20206242   PMID:20498066   PMID:21209331   PMID:21412429   PMID:21445260   PMID:21539826   PMID:21677750   PMID:21873635   PMID:22560297  
PMID:23364326   PMID:24995796   PMID:25810521   PMID:30651295   PMID:31038803   PMID:31869353  


Genomics

Comparative Map Data
Gdf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39128,347,918 - 8,351,954 (-)NCBI
GRCm38128,297,918 - 8,301,954 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl128,297,918 - 8,301,954 (-)EnsemblGRCm38mm10GRCm38
MGSCv37128,304,724 - 8,308,760 (-)NCBIGRCm37mm9NCBIm37
MGSCv36128,323,926 - 8,327,962 (-)NCBImm8
Celera128,691,764 - 8,695,838 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
GDF7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl220,667,144 - 20,679,243 (+)EnsemblGRCh38hg38GRCh38
GRCh38220,667,144 - 20,679,243 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37220,866,424 - 20,871,250 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36220,729,905 - 20,734,731 (+)NCBINCBI36hg18NCBI36
Build 34220,788,051 - 20,792,878NCBI
Celera220,728,800 - 20,733,639 (+)NCBI
Cytogenetic Map2p24.1NCBI
HuRef220,623,337 - 20,628,206 (+)NCBIHuRef
CHM1_1220,795,793 - 20,800,641 (+)NCBICHM1_1
Gdf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0633,496,596 - 33,507,626 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl633,503,217 - 33,507,542 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0643,281,722 - 43,292,667 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4631,857,104 - 31,861,428 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1631,860,390 - 31,860,592 (-)NCBI
Celera630,628,297 - 30,632,622 (-)NCBICelera
Cytogenetic Map6q14NCBI
Gdf7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554693,134,355 - 3,149,177 (+)NCBIChiLan1.0ChiLan1.0
GDF7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A20,766,776 - 20,773,082 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v02A20,651,617 - 20,664,586 (+)NCBIMhudiblu_PPA_v0panPan3
GDF7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11715,627,739 - 15,636,513 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gdf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649310,808,714 - 10,812,761 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3117,588,431 - 117,592,466 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13117,586,188 - 117,592,541 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23125,548,358 - 125,553,115 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GDF7
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1487,023,028 - 87,027,194 (-)Ensembl
ChlSab1.11487,013,821 - 87,027,977 (-)NCBI
Gdf7
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247383,281,828 - 3,286,627 (+)NCBI

Position Markers
Gdf7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38128,298,012 - 8,298,147UniSTSGRCm38
MGSCv37128,304,818 - 8,304,953UniSTSGRCm37
Celera128,691,858 - 8,691,993UniSTS
Cytogenetic Map12A1.1UniSTS
cM Map12 UniSTS
PMC317230P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38128,297,877 - 8,298,014UniSTSGRCm38
MGSCv37128,304,683 - 8,304,820UniSTSGRCm37
Celera128,691,723 - 8,691,860UniSTS
Cytogenetic Map12A1.1UniSTS
Gdf7  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38128,297,614 - 8,297,909UniSTSGRCm38
MGSCv37128,304,420 - 8,304,715UniSTSGRCm37
Celera128,691,460 - 8,691,755UniSTS
Cytogenetic Map12A1.1UniSTS
cM Map12 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
CRRD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301393Dyscalc3_mdystrophic cardiac calcinosis 3 (mouse)Not determined12122368579Mouse
1301143Skull17_mskull morphology 17 (mouse)Not determined12122368579Mouse
10402496Lmr22_mleishmaniasis resistance 22 (mouse)Not determined12122368579Mouse
11039525Tbbr2_mTrypanosoma brucei brucei response 2 (mouse)12122368579Mouse
1301655Bmd12_mbone mineral density 12 (mouse)Not determined12124612697Mouse
1357519Vtbt12_mvertebral trabecular bone trait 12 (mouse)Not determined12124612697Mouse
4141296Femwf9_mfemur work to failure 9 (mouse)Not determined127870733Mouse
4141112Tglq2a_mtriglyceride QTL 2a (mouse)Not determined12127870733Mouse
4141436Chldq7_mcholesterol and HDL QTL 7 (mouse)Not determined12127870733Mouse
9850128Tglq5_mtriglyceride QTL 5 (mouse)Not determined12127870733Mouse
12910983Pifs1_mpeptide-induced fatal syndrome 1 (mouse)12130383077Mouse
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132708755Mouse
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133380338Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1229013334290301Mouse
26884410Bzwq15_mbi-zygomatic width QTL 15, 16 week (mouse)12360000029700000Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12536844076984429Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12767315941673302Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12800000040000000Mouse
25394547Skmw75_mskeletal muscle weight 75, gastroc (mouse)12816257610401853Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:190
Count of miRNA genes:170
Interacting mature miRNAs:184
Transcripts:ENSMUST00000037313
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000037313   ⟹   ENSMUSP00000038301
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl128,297,918 - 8,301,954 (-)Ensembl
RefSeq Acc Id: ENSMUST00000220073   ⟹   ENSMUSP00000151234
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl128,297,918 - 8,301,954 (-)Ensembl
RefSeq Acc Id: NM_001312876   ⟹   NP_001299805
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39128,347,918 - 8,351,954 (-)NCBI
GRCm38128,297,918 - 8,301,954 (-)NCBI
Sequence:
RefSeq Acc Id: NM_013527   ⟹   NP_038555
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39128,347,918 - 8,351,954 (-)NCBI
GRCm38128,297,918 - 8,301,954 (-)NCBI
MGSCv37128,304,724 - 8,308,760 (-)RGD
Celera128,691,764 - 8,695,838 (-)RGD
cM Map12 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001299805 (Get FASTA)   NCBI Sequence Viewer  
  NP_038555 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA18780 (Get FASTA)   NCBI Sequence Viewer  
  AAK30843 (Get FASTA)   NCBI Sequence Viewer  
  AAP97721 (Get FASTA)   NCBI Sequence Viewer  
  P43029 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_038555   ⟸   NM_013527
- Peptide Label: isoform 2 preproprotein
- UniProtKB: P43029 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001299805   ⟸   NM_001312876
- Peptide Label: isoform 1 preproprotein
- UniProtKB: P43029 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000038301   ⟸   ENSMUST00000037313
RefSeq Acc Id: ENSMUSP00000151234   ⟸   ENSMUST00000220073

Promoters
RGD ID:8677882
Promoter ID:EPDNEW_M16971
Type:multiple initiation site
Name:Gdf7_1
Description:Mus musculus growth differentiation factor 7 , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38128,301,988 - 8,302,048EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95690 AgrOrtholog
Ensembl Genes ENSMUSG00000037660 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000038301 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000151234 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000037313 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000220073 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot
  TGF-b_C UniProtKB/Swiss-Prot
  TGF-b_propeptide UniProtKB/Swiss-Prot
  TGF-beta-rel UniProtKB/Swiss-Prot
  TGFb_CS UniProtKB/Swiss-Prot
KEGG Report mmu:238057 UniProtKB/Swiss-Prot
MGD MGI:95690 ENTREZGENE
NCBI Gene 238057 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot
Pfam TGF_beta UniProtKB/Swiss-Prot
  TGFb_propeptide UniProtKB/Swiss-Prot
PhenoGen Gdf7 PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot
  TGF_BETA_2 UniProtKB/Swiss-Prot
SMART TGFB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot
UniGene Mm.271308 ENTREZGENE
UniProt GDF7_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q7TNX4 UniProtKB/Swiss-Prot
  Q99MY1 UniProtKB/Swiss-Prot