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Gene: MAP3K4 (mitogen-activated protein kinase kinase kinase 4) Homo sapiens
Symbol: MAP3K4
Name: mitogen-activated protein kinase kinase kinase 4
Description: Exhibits MAP kinase kinase kinase activity. Involved in positive regulation of macromolecule metabolic process and response to UV-C. Localizes to cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4); FLJ42439; KIAA0213; MAP three kinase 1; MAP/ERK kinase kinase 4; MAPK/ERK kinase kinase 4; MAPKKK4; MEK kinase 4; MEKK 4; MEKK4; MTK1; predicted protein of HQ0412; PRO0412; SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of
Mus musculus (house mouse) : Map3k4 (mitogen-activated protein kinase kinase kinase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Map3k4 (mitogen activated protein kinase kinase kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map3k4 (mitogen-activated protein kinase kinase kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP3K4 (mitogen-activated protein kinase kinase kinase 4)
Canis lupus familiaris (dog) : MAP3K4 (mitogen-activated protein kinase kinase kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Map3k4 (mitogen-activated protein kinase kinase kinase 4)
Sus scrofa (pig) : MAP3K4 (mitogen-activated protein kinase kinase kinase 4)
Chlorocebus sabaeus (African green monkey) : MAP3K4 (mitogen-activated protein kinase kinase kinase 4)
Heterocephalus glaber (naked mole-rat) : Map3k4 (mitogen-activated protein kinase kinase kinase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl6160,991,727 - 161,117,385 (+)EnsemblGRCh38hg38GRCh38
GRCh386160,991,521 - 161,117,385 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376161,412,816 - 161,538,417 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366161,332,812 - 161,458,407 (+)NCBINCBI36hg18NCBI36
Build 346161,383,232 - 161,508,827NCBI
Celera6162,142,470 - 162,267,820 (+)NCBI
Cytogenetic Map6q26NCBI
HuRef6158,868,162 - 158,993,547 (+)NCBIHuRef
CHM1_16161,675,631 - 161,801,069 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MAP3K4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322520
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.