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Gene: PDCD6 (programmed cell death 6) Homo sapiens
Symbol: PDCD6
Name: programmed cell death 6
Description: Exhibits several functions, including calcium-dependent protein binding activity; protein binding activity, bridging; and protein homodimerization activity. Involved in several processes, including mesenchymal cell differentiation; negative regulation of signal transduction; and positive regulation of cellular protein metabolic process. Localizes to several cellular components, including COPII vesicle coat; Cul3-RING ubiquitin ligase complex; and endoplasmic reticulum exit site.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ALG-2; ALG2; apoptosis-linked gene 2 protein; apoptosis-linked gene 2 protein homolog; apoptosis-linked gene-2; FLJ42309; FLJ46208; MGC111017; MGC119050; MGC9123; PEF1B; probable calcium-binding protein ALG-2; programmed cell death protein 6
Mus musculus (house mouse) : Pdcd6 (programmed cell death 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdcd6 (programmed cell death 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdcd6 (programmed cell death 6)
Pan paniscus (bonobo/pygmy chimpanzee) : PDCD6 (programmed cell death 6)
Canis lupus familiaris (dog) : PDCD6 (programmed cell death 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdcd6 (programmed cell death 6)
Sus scrofa (pig) : PDCD6 (programmed cell death 6)
Chlorocebus sabaeus (African green monkey) : PDCD6 (programmed cell death 6)
Heterocephalus glaber (naked mole-rat) : Pdcd6 (programmed cell death 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: ALG2 (Gene ID: 85365) and PDCD6 (Gene ID: 10016) share the ALG2 symbol/alias in common. ALG2 is a widely used alternative name for programmed cell death 6 (PDCD6), whose synonym is apoptosis-linked gene-2. This can be confused with the official symbol for ALG2, alpha-1,3/1,6-mannosyltransferase (ALG2). [31 May 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5271,621 - 314,974 (+)EnsemblGRCh38hg38GRCh38
GRCh385271,621 - 314,974 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375271,736 - 315,089 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365324,736 - 368,089 (+)NCBINCBI36hg18NCBI36
Build 345324,738 - 368,089NCBI
Celera5370,282 - 413,335 (+)NCBI
Cytogenetic Map5p15.33NCBI
HuRef5258,986 - 302,543 (+)NCBIHuRef
CHM1_15267,028 - 314,783 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on PDCD6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322592
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.