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Gene: ALYREF (Aly/REF export factor) Homo sapiens
Symbol: ALYREF
Name: Aly/REF export factor
Description: Exhibits C5-methylcytidine-containing RNA binding activity. Involved in several processes, including mRNA export from nucleus; regulation of nucleobase-containing compound metabolic process; and viral mRNA export from host cell nucleus. Localizes to cytoplasm and nucleus. Colocalizes with exon-exon junction complex and nuclear chromosome, telomeric region.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ally of AML-1 and LEF-1; ALY; ALY/REF; BEF; bZIP enhancing factor; bZIP-enhancing factor BEF; REF; THO complex 4; THO complex subunit 4; tho4; THOC4; transcriptional coactivator Aly/REF
Mus musculus (house mouse) : Alyref (Aly/REF export factor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Alyref (Aly/REF export factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Alyref (Aly/REF export factor)
Pan paniscus (bonobo/pygmy chimpanzee) : ALYREF (Aly/REF export factor)
Canis lupus familiaris (dog) : ALYREF (Aly/REF export factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Alyref (Aly/REF export factor)
Sus scrofa (pig) : ALYREF (Aly/REF export factor)
Chlorocebus sabaeus (African green monkey) : ALYREF (Aly/REF export factor)
Heterocephalus glaber (naked mole-rat) : Alyref (Aly/REF export factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1781,887,835 - 81,891,586 (-)EnsemblGRCh38hg38GRCh38
GRCh381781,887,835 - 81,891,587 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371779,845,711 - 79,849,464 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,439,016 - 77,442,758 (-)NCBINCBI36hg18NCBI36
Build 341777,439,016 - 77,442,758NCBI
Celera1776,449,564 - 76,453,306 (-)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1775,247,636 - 75,251,146 (-)NCBIHuRef
CHM1_11779,931,915 - 79,935,666 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ALYREF
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322669
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.