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Gene: Frzb (frizzled-related protein) Mus musculus
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Symbol: Frzb
Name: frizzled-related protein
Description: Exhibits Wnt-protein binding activity. Involved in several processes, including animal organ development; negative regulation of cartilage development; and negative regulation of cell differentiation. Localizes to the extracellular space. Human ortholog(s) of this gene implicated in osteoarthritis. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human FRZB (frizzled related protein); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: frezzled; fritz; frizzled-related protein 1; Frp; frzb-1; secreted frizzled-related protein 3; secreted frizzled-related sequence protein 3; sFRP-3; Sfrp3
Orthologs:
Homo sapiens (human) : FRZB (frizzled related protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Frzb (frizzled-related protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Frzb (frizzled related protein)
Pan paniscus (bonobo/pygmy chimpanzee) : FRZB (frizzled related protein)
Canis lupus familiaris (dog) : FRZB (frizzled related protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Frzb (frizzled related protein)
Sus scrofa (pig) : FRZB (frizzled related protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38280,411,970 - 80,447,396 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37280,252,127 - 80,287,553 (-)NCBIGRCm37mm9NCBIm37
MGSCv36280,212,809 - 80,248,235 (-)NCBImm8
Celera282,075,833 - 82,112,383 (-)NCBICelera
Cytogenetic Map2 C3NCBI
cM Map248.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Frzb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322705
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.