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Gene: Frzb (frizzled-related protein) Mus musculus
Symbol: Frzb
Name: frizzled-related protein
Description: Exhibits Wnt-protein binding activity. Involved in several processes, including animal organ development; negative regulation of cartilage development; and negative regulation of cell differentiation. Localizes to the extracellular space. Human ortholog(s) of this gene implicated in osteoarthritis. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Orthologous to human FRZB (frizzled related protein); PARTICIPATES IN Wnt signaling, canonical pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: frezzled; fritz; frizzled-related protein 1; Frp; frzb-1; secreted frizzled-related protein 3; secreted frizzled-related sequence protein 3; sFRP-3; Sfrp3
Homo sapiens (human) : FRZB (frizzled related protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Frzb (frizzled-related protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Frzb (frizzled related protein)
Pan paniscus (bonobo/pygmy chimpanzee) : FRZB (frizzled related protein)
Canis lupus familiaris (dog) : FRZB (frizzled related protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Frzb (frizzled related protein)
Sus scrofa (pig) : FRZB (frizzled related protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38280,411,970 - 80,447,396 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37280,252,127 - 80,287,553 (-)NCBIGRCm37mm9NCBIm37
MGSCv36280,212,809 - 80,248,235 (-)NCBImm8
Celera282,075,833 - 82,112,383 (-)NCBICelera
Cytogenetic Map2 C3NCBI
cM Map248.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Frzb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322705
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.