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Gene: OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1) Homo sapiens
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Symbol: OTUB1
Name: OTU deubiquitinase, ubiquitin aldehyde binding 1
Description: Exhibits ubiquitin binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein-specific protease activity. Involved in cellular response to DNA damage stimulus; negative regulation of nitrogen compound metabolic process; and protein K48-linked deubiquitination. Localizes to extracellular exosome. Biomarker of IgA glomerulonephritis and lupus nephritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deubiquitinating enzyme OTUB1; FLJ20113; FLJ40710; hOTU1; HSPC263; MGC111158; MGC4584; OTB1; OTU domain, ubiquitin aldehyde binding 1; OTU domain-containing ubiquitin aldehyde-binding protein 1; OTU-domain Ubal-binding 1; OTU1; otubain-1; ubiquitin thioesterase OTUB1; ubiquitin-specific protease otubain 1; ubiquitin-specific-processing protease OTUB1
Orthologs:
Mus musculus (house mouse) : Otub1 (OTU domain, ubiquitin aldehyde binding 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Otub1 (OTU deubiquitinase, ubiquitin aldehyde binding 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Otub1 (OTU deubiquitinase, ubiquitin aldehyde binding 1)
Pan paniscus (bonobo/pygmy chimpanzee) : OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1)
Canis lupus familiaris (dog) : OTUB1 (OTU domain, ubiquitin aldehyde binding 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Otub1 (OTU deubiquitinase, ubiquitin aldehyde binding 1)
Sus scrofa (pig) : OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1)
Chlorocebus sabaeus (African green monkey) : OTUB1 (OTU deubiquitinase, ubiquitin aldehyde binding 1)
Heterocephalus glaber (naked mole-rat) : Otub1 (OTU deubiquitinase, ubiquitin aldehyde binding 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1163,985,853 - 64,001,811 (+)EnsemblGRCh38hg38GRCh38
GRCh381163,985,853 - 63,998,420 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371163,753,325 - 63,765,892 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361163,509,901 - 63,522,468 (+)NCBINCBI36hg18NCBI36
Build 341163,510,460 - 63,522,463NCBI
Celera1161,080,100 - 61,092,667 (+)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1160,082,024 - 60,094,513 (+)NCBIHuRef
CHM1_11163,636,649 - 63,649,224 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Nomenclature History
 
More on OTUB1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322723
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.