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Gene: SLC12A6 (solute carrier family 12 member 6) Homo sapiens
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Symbol: SLC12A6
Name: solute carrier family 12 member 6
CRRD ID: 1322734
Description: Exhibits ammonium transmembrane transporter activity; potassium:chloride symporter activity; and protein kinase binding activity. Involved in ammonium import across plasma membrane; cellular hypotonic salinity response; and potassium ion import across plasma membrane. Predicted to localize to axon and basolateral plasma membrane. Implicated in agenesis of the corpus callosum with peripheral neuropathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ACCPN; DKFZp434D2135; electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3; KCC3; KCC3A; KCC3B; potassium chloride cotransporter 3; potassium chloride cotransporter KCC3a-S3; potassium-chloride transporter-3a; potassium-chloride transporter-3b; solute carrier family 12 (potassium/chloride transporter), member 6; solute carrier family 12 (potassium/chloride transporters), member 6
Orthologs:
Mus musculus (house mouse) : Slc12a6 (solute carrier family 12, member 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc12a6 (solute carrier family 12, member 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc12a6 (solute carrier family 12 member 6)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC12A6 (solute carrier family 12 member 6)
Canis lupus familiaris (dog) : SLC12A6 (solute carrier family 12 member 6)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc12a6 (solute carrier family 12 member 6)
Sus scrofa (pig) : SLC12A6 (solute carrier family 12 member 6)
Chlorocebus sabaeus (African green monkey) : SLC12A6 (solute carrier family 12 member 6)
Heterocephalus glaber (naked mole-rat) : Slc12a6 (solute carrier family 12 member 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1534,229,784 - 34,338,060 (-)EnsemblGRCh38hg38GRCh38
GRCh381534,229,784 - 34,338,057 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371534,522,197 - 34,630,265 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361532,309,489 - 32,417,557 (-)NCBINCBI36hg18NCBI36
Build 341532,312,957 - 32,398,222NCBI
Celera1511,324,764 - 11,432,905 (-)NCBI
Cytogenetic Map15q14NCBI
HuRef1511,385,680 - 11,493,609 (-)NCBIHuRef
CHM1_11534,640,225 - 34,748,321 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SLC12A6
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1322734
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.