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Gene: DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit) Homo sapiens
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Symbol: DEPDC5
Name: DEP domain containing 5, GATOR1 subcomplex subunit
CRRD ID: 1323042
Description: Contributes to GTPase activator activity. Involved in cellular response to amino acid starvation and negative regulation of TORC1 signaling. Localizes to GATOR1 complex and lysosomal membrane. Colocalizes with Cul3-RING ubiquitin ligase complex. Implicated in focal epilepsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DEP domain containing 5; DEP domain-containing protein 5; DEP.5; DKFZp779P2027; FFEVF; FFEVF1; GATOR complex protein DEPDC5
Orthologs:
Mus musculus (house mouse) : Depdc5 (DEP domain containing 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Depdc5 (DEP domain containing 5, GATOR1 subcomplex subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Depdc5 (DEP domain containing 5, GATOR1 subcomplex subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit)
Canis lupus familiaris (dog) : DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Depdc5 (DEP domain containing 5, GATOR1 subcomplex subunit)
Sus scrofa (pig) : DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit)
Chlorocebus sabaeus (African green monkey) : DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit)
Heterocephalus glaber (naked mole-rat) : Depdc5 (DEP domain containing 5, GATOR1 subcomplex subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2231,753,867 - 31,908,033 (+)EnsemblGRCh38hg38GRCh38
GRCh382231,753,968 - 31,908,033 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372232,149,937 - 32,303,020 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362230,480,069 - 30,633,001 (+)NCBINCBI36hg18NCBI36
Build 342230,474,622 - 30,627,554NCBI
Celera2215,950,512 - 16,103,452 (+)NCBI
Cytogenetic Map22q12.2-q12.3NCBI
HuRef2215,105,131 - 15,259,327 (+)NCBIHuRef
CHM1_12232,109,512 - 32,262,422 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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