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Gene: SIN3A (SIN3 transcription regulator family member A) Homo sapiens
Symbol: SIN3A
Name: SIN3 transcription regulator family member A
Description: Exhibits RNA polymerase II activating transcription factor binding activity and protein deacetylase activity. Predicted to contribute to histone deacetylase activity. Involved in several processes, including negative regulation of histone H3-K27 acetylation; regulation of defense response; and regulation of transcription, DNA-templated. Localizes to the Sin3 complex. Implicated in chromosome 15q24 deletion syndrome. Biomarker of Huntington's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp434K2235; FLJ90319; histone deacetylase complex subunit Sin3a; KIAA0700; paired amphipathic helix protein Sin3a; SIN3 homolog A, transcription regulator; SIN3 transcription regulator homolog A; transcriptional co-repressor Sin3A; transcriptional corepressor Sin3a; transcriptional regulator, SIN3A; WITKOS
Mus musculus (house mouse) : Sin3a (transcriptional regulator, SIN3A (yeast))  MGI  Alliance
Rattus norvegicus (Norway rat) : Sin3a (SIN3 transcription regulator family member A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sin3a (SIN3 transcription regulator family member A)
Pan paniscus (bonobo/pygmy chimpanzee) : SIN3A (SIN3 transcription regulator family member A)
Canis lupus familiaris (dog) : SIN3A (SIN3 transcription regulator family member A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sin3a (SIN3 transcription regulator family member A)
Sus scrofa (pig) : SIN3A (SIN3 transcription regulator family member A)
Chlorocebus sabaeus (African green monkey) : SIN3A (SIN3 transcription regulator family member A)
Heterocephalus glaber (naked mole-rat) : Sin3a (SIN3 transcription regulator family member A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1575,369,379 - 75,455,842 (-)Ensembl
GRCh381575,369,379 - 75,455,819 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371575,661,720 - 75,748,181 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361573,450,328 - 73,530,979 (-)NCBINCBI36hg18NCBI36
Build 341573,450,329 - 73,530,979NCBI
Celera1552,588,161 - 52,674,772 (-)NCBI
Cytogenetic Map15q24.2NCBI
HuRef1552,420,097 - 52,506,377 (-)NCBIHuRef
CHM1_11575,780,322 - 75,866,699 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SIN3A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323140
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.