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Gene: FURIN (furin, paired basic amino acid cleaving enzyme) Homo sapiens
Symbol: FURIN
Name: furin, paired basic amino acid cleaving enzyme
CRRD ID: 1323167
Description: Exhibits several functions, including nerve growth factor binding activity; serine-type endopeptidase activity; and serine-type endopeptidase inhibitor activity. Involved in several processes, including protein processing; regulation of protein metabolic process; and regulation of transforming growth factor beta1 production. Localizes to several cellular components, including Golgi apparatus; membrane raft; and trans-Golgi network transport vesicle. Biomarker of arteriosclerosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dibasic processing enzyme; dibasic-processing enzyme; FES upstream region; FUR; furin (paired basic amino acid cleaving enzyme); furin, membrane associated receptor protein; FURIN/ADAMTS1 fusion; PACE; paired basic amino acid residue-cleaving enzyme; PCSK3; proprotein convertase subtilisin/kexin type 3; SPC1
Mus musculus (house mouse) : Furin (furin (paired basic amino acid cleaving enzyme))  MGI  Alliance
Rattus norvegicus (Norway rat) : Furin (furin (paired basic amino acid cleaving enzyme))  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Furin (furin, paired basic amino acid cleaving enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : FURIN (furin, paired basic amino acid cleaving enzyme)
Canis lupus familiaris (dog) : FURIN (furin, paired basic amino acid cleaving enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Furin (furin, paired basic amino acid cleaving enzyme)
Sus scrofa (pig) : FURIN (furin, paired basic amino acid cleaving enzyme)
Chlorocebus sabaeus (African green monkey) : FURIN (furin, paired basic amino acid cleaving enzyme)
Heterocephalus glaber (naked mole-rat) : Furin (furin, paired basic amino acid cleaving enzyme)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1590,868,588 - 90,883,458 (+)EnsemblGRCh38hg38GRCh38
GRCh381590,868,588 - 90,883,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371591,411,885 - 91,426,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,212,889 - 89,227,691 (+)NCBINCBI36hg18NCBI36
Build 341589,212,888 - 89,227,691NCBI
Celera1567,820,515 - 67,835,658 (+)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1567,523,022 - 67,538,192 (+)NCBIHuRef
CHM1_11591,253,391 - 91,268,262 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on FURIN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323167
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.