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Gene: Itk (IL2 inducible T cell kinase) Mus musculus
Symbol: Itk
Name: IL2 inducible T cell kinase
Description: Predicted to have non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including NK T cell differentiation; T cell receptor signaling pathway; and activation of phospholipase C activity. Localizes to the cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; acetohydrazide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Emt; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; interleukin-2-inducible T cell kinase; kinase EMT; kinase TLK; T-cell-specific kinase; Tcsk; Tsk; tyrosine-protein kinase ITK/TSK
Homo sapiens (human) : ITK (IL2 inducible T cell kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itk (IL2-inducible T-cell kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itk (IL2 inducible T cell kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : ITK (IL2 inducible T cell kinase)
Canis lupus familiaris (dog) : ITK (IL2 inducible T cell kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itk (IL2 inducible T cell kinase)
Sus scrofa (pig) : ITK (IL2 inducible T cell kinase)
Chlorocebus sabaeus (African green monkey) : ITK (IL2 inducible T cell kinase)
Heterocephalus glaber (naked mole-rat) : Itk (IL2 inducible T cell kinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1146,325,150 - 46,389,515 (-)EnsemblGRCm38mm10GRCm38
GRCm381146,325,148 - 46,389,515 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371146,138,652 - 46,203,017 (-)NCBIGRCm37mm9NCBIm37
MGSCv361146,168,576 - 46,232,923 (-)NCBImm8
Celera1150,911,124 - 50,975,428 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1127.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Itk
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323170
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.