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Gene: Itk (IL2 inducible T cell kinase) Mus musculus
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Symbol: Itk
Name: IL2 inducible T cell kinase
Description: Predicted to have non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including NK T cell differentiation; T cell receptor signaling pathway; and activation of phospholipase C activity. Localizes to the cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase); PARTICIPATES IN phosphatidylinositol 3-kinase class I signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; acetohydrazide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Emt; IL-2-inducible T-cell kinase; IL2-inducible T-cell kinase; interleukin-2-inducible T cell kinase; kinase EMT; kinase TLK; T-cell-specific kinase; Tcsk; Tsk; tyrosine-protein kinase ITK/TSK
Orthologs:
Homo sapiens (human) : ITK (IL2 inducible T cell kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Itk (IL2-inducible T-cell kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itk (IL2 inducible T cell kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : ITK (IL2 inducible T cell kinase)
Canis lupus familiaris (dog) : ITK (IL2 inducible T cell kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itk (IL2 inducible T cell kinase)
Sus scrofa (pig) : ITK (IL2 inducible T cell kinase)
Chlorocebus sabaeus (African green monkey) : ITK (IL2 inducible T cell kinase)
Heterocephalus glaber (naked mole-rat) : Itk (IL2 inducible T cell kinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1146,325,150 - 46,389,515 (-)EnsemblGRCm38mm10GRCm38
GRCm381146,325,148 - 46,389,515 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371146,138,652 - 46,203,017 (-)NCBIGRCm37mm9NCBIm37
MGSCv361146,168,576 - 46,232,923 (-)NCBImm8
Celera1150,911,124 - 50,975,428 (-)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1127.75NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Itk
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323170
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.