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Gene: Kmt5b (lysine methyltransferase 5B) Mus musculus
Symbol: Kmt5b
Name: lysine methyltransferase 5B
Description: Exhibits histone methyltransferase activity (H4-K20 specific). Involved in histone H4-K20 methylation. Localizes to the condensed nuclear chromosome, centromeric region. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 51. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; liver; and lung. Orthologous to human KMT5B (lysine methyltransferase 5B); PARTICIPATES IN histone modification pathway; lysine degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA117471; C630029K18Rik; histone-lysine N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H1; lysine-specific methyltransferase 5B; MGC18702; su(var)4-20 homolog 1; suppressor of variegation 4-20 homolog 1; suppressor of variegation 4-20 homolog 1 (Drosophila); Suv4-20h1; Suv420h1
Homo sapiens (human) : KMT5B (lysine methyltransferase 5B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Kmt5b (lysine methyltransferase 5B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kmt5b (lysine methyltransferase 5B)
Pan paniscus (bonobo/pygmy chimpanzee) : KMT5B (lysine methyltransferase 5B)
Canis lupus familiaris (dog) : KMT5B (lysine methyltransferase 5B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kmt5b (lysine methyltransferase 5B)
Sus scrofa (pig) : KMT5B (lysine methyltransferase 5B)
Chlorocebus sabaeus (African green monkey) : KMT5B (lysine methyltransferase 5B)
Heterocephalus glaber (naked mole-rat) : Kmt5b (lysine methyltransferase 5B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl193,767,421 - 3,818,303 (+)Ensembl
GRCm38193,767,362 - 3,818,303 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37193,767,421 - 3,818,303 (+)NCBIGRCm37mm9NCBIm37
MGSCv36193,767,421 - 3,816,391 (+)NCBImm8
Celera193,646,536 - 3,697,352 (+)NCBICelera
Cytogenetic Map19 ANCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Kmt5b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323199
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.