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Gene: CNOT2 (CCR4-NOT transcription complex subunit 2) Homo sapiens
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Symbol: CNOT2
Name: CCR4-NOT transcription complex subunit 2
CRRD ID: 1323253
Description: Exhibits RNA polymerase II transcription corepressor binding activity. Contributes to poly(A)-specific ribonuclease activity. Involved in several processes, including negative regulation of intracellular estrogen receptor signaling pathway; positive regulation of cytoplasmic mRNA processing body assembly; and regulation of stem cell population maintenance. Localizes to several cellular components, including CCR4-NOT complex; cytosol; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CCR4-associated factor 2; CCR4-NOT transcription complex, subunit 2; CDC36; FLJ26456; HSPC131; IDNADFS; negative regulator of transcription 2; NOT2; NOT2 (negative regulator of transcription 2, yeast) homolog; NOT2H
Orthologs:
Mus musculus (house mouse) : Cnot2 (CCR4-NOT transcription complex, subunit 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cnot2 (CCR4-NOT transcription complex, subunit 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cnot2 (CCR4-NOT transcription complex subunit 2)
Pan paniscus (bonobo/pygmy chimpanzee) : CNOT2 (CCR4-NOT transcription complex subunit 2)
Canis lupus familiaris (dog) : CNOT2 (CCR4-NOT transcription complex subunit 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cnot2 (CCR4-NOT transcription complex subunit 2)
Sus scrofa (pig) : CNOT2 (CCR4-NOT transcription complex subunit 2)
Chlorocebus sabaeus (African green monkey) : CNOT2 (CCR4-NOT transcription complex subunit 2)
Heterocephalus glaber (naked mole-rat) : Cnot2 (CCR4-NOT transcription complex subunit 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1270,242,994 - 70,354,993 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1270,242,994 - 70,355,257 (+)EnsemblGRCh38hg38GRCh38
GRCh381270,242,993 - 70,354,993 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371270,636,774 - 70,748,773 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361268,923,044 - 69,035,040 (+)NCBINCBI36hg18NCBI36
Build 341268,923,488 - 69,033,960NCBI
Celera1270,300,448 - 70,412,447 (+)NCBI
Cytogenetic Map12q15NCBI
HuRef1267,686,934 - 67,798,932 (+)NCBIHuRef
CHM1_11270,606,077 - 70,718,081 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CNOT2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323253
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.