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Gene: Lrrc8a (leucine rich repeat containing 8A VRAC subunit A) Mus musculus
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Symbol: Lrrc8a
Name: leucine rich repeat containing 8A VRAC subunit A
Description: Predicted to contribute to anion channel activity. Predicted to be involved in cell volume homeostasis; cellular response to osmotic stress; and organic acid transport. Predicted to localize to several cellular components, including cell surface; integral component of plasma membrane; and ion channel complex. Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 5. Orthologous to human LRRC8A (leucine rich repeat containing 8 VRAC subunit A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ebo; leucine rich repeat containing 8A; leucine-rich repeat-containing 8; leucine-rich repeat-containing protein 8A; Lrrc8; MGC61242; mKIAA1437; SWELL1; volume-regulated anion channel subunit LRRC8A
Orthologs:
Homo sapiens (human) : LRRC8A (leucine rich repeat containing 8 VRAC subunit A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lrrc8a (leucine rich repeat containing 8 VRAC subunit A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrrc8a (leucine rich repeat containing 8 VRAC subunit A)
Pan paniscus (bonobo/pygmy chimpanzee) : LRRC8A (leucine rich repeat containing 8 VRAC subunit A)
Canis lupus familiaris (dog) : LRRC8A (leucine rich repeat containing 8 VRAC subunit A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrrc8a (leucine rich repeat containing 8 VRAC subunit A)
Sus scrofa (pig) : LRRC8A (leucine rich repeat containing 8 VRAC subunit A)
Chlorocebus sabaeus (African green monkey) : LRRC8A (leucine rich repeat containing 8 VRAC subunit A)
Heterocephalus glaber (naked mole-rat) : Lrrc8a (leucine rich repeat containing 8 VRAC subunit A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl230,240,567 - 30,282,148 (+)EnsemblGRCm38mm10GRCm38
GRCm38 Ensembl230,237,715 - 30,263,790 (+)EnsemblGRCm38mm10GRCm38
GRCm38230,237,769 - 30,263,790 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37230,093,289 - 30,119,310 (+)NCBIGRCm37mm9NCBIm37
MGSCv36230,059,778 - 30,085,799 (+)NCBImm8
Celera229,942,159 - 29,968,181 (+)NCBICelera
Cytogenetic Map2BNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Lrrc8a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323280
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.