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Gene: GFI1B (growth factor independent 1B transcriptional repressor) Homo sapiens
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Symbol: GFI1B
Name: growth factor independent 1B transcriptional repressor
Description: Exhibits RNA polymerase II transcription factor binding activity. Involved in negative regulation of transcription by RNA polymerase II. Localizes to the nuclear lumen; plasma membrane; and transcription factor complex. Implicated in gray platelet syndrome and platelet-type bleeding disorder 17. Biomarker of acute myeloid leukemia; aplastic anemia; megakaryocytic leukemia; myeloid neoplasm; and precursor lymphoblastic lymphoma/leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BDPLT17; growth factor independent 1B (potential regulator of CDKN1A, translocated in CML); growth factor independent 1B transcription repressor; growth factor independent protein 1B; potential regulator of CDKN1A translocated in CML; zinc finger protein Gfi-1b; ZNF163B
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389132,945,545 - 132,991,697 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379135,820,888 - 135,867,084 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369134,843,919 - 134,856,903 (+)NCBINCBI36hg18NCBI36
Build 349132,883,651 - 132,896,636NCBI
Celera9106,395,838 - 106,408,823 (+)NCBI
Cytogenetic Map9q34.13NCBI
HuRef9105,347,908 - 105,360,763 (+)NCBIHuRef
CHM1_19135,971,359 - 136,017,406 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GFI1B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323334
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.