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Gene: Akr1c21 (aldo-keto reductase family 1, member C21) Mus musculus
Symbol: Akr1c21
Name: aldo-keto reductase family 1, member C21
Description: Exhibits NADP binding activity; lithocholic acid binding activity; and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in oxidation-reduction process. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in 46 XY gonadal dysgenesis; leukemia; precursor B lymphoblastic lymphoma/leukemia; and precursor T-lymphoblastic lymphoma/leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3); INTERACTS WITH 17alpha-ethynylestradiol; 4,4'-diaminodiphenylmethane; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 17-alpha-HSD; 17-alpha-hydroxysteroid dehydrogenase; 3(17)alpha-hydroxysteroid dehydrogenase; 3(or 17)-alpha-hydroxysteroid dehydrogenase; 3-alpha-hydroxysteroid dehydrogenase; 9430025F20Rik; AI315367; aldo-keto reductase family 1 member C21; DD1; DD3; dihydrodiol dehydrogenase type 1; dihydrodiol dehydrogenase type 3; MGC102401
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38134,574,075 - 4,586,543 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37134,573,321 - 4,585,789 (+)NCBIGRCm37mm9NCBIm37
MGSCv36134,573,321 - 4,585,787 (+)NCBImm8
Celera134,543,969 - 4,562,535 (+)NCBICelera
Cytogenetic Map13 A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Akr1c21
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323510
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.