Gene: Slc22a12 (solute carrier family 22 (organic anion/cation transporter), member 12) Mus musculus
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Symbol:
Slc22a12
Name:
solute carrier family 22 (organic anion/cation transporter), member 12
Description:
Exhibits urate transmembrane transporter activity. Involved in urate transport. Localizes to the brush border membrane and integral component of membrane. Is expressed in central nervous system; dorsal root ganglion; male reproductive gland or organ; metanephros; and retina layer. Orthologous to human SLC22A12 (solute carrier family 22 member 12); INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
AI987855; OAT4L; renal-specific transporter; Rst; Slc22al2; solute carrier family 22 (organic cation transporter)-like 2; solute carrier family 22 member 12; URAT1; urate anion exchanger 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SLC22A12 (solute carrier family 22 member 12) HGNC
Ensembl, HGNC, HomoloGene, Inparanoid, OMA, OrthoDB, Panther, Treefam
Rattus norvegicus (Norway rat):
Slc22a12 (solute carrier family 22 member 12) HGNC
HomoloGene, Panther
Chinchilla lanigera (long-tailed chinchilla):
Slc22a12 (solute carrier family 22 member 12) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SLC22A12 (solute carrier family 22 member 12) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SLC22A12 (solute carrier family 22 member 12) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Slc22a12 (solute carrier family 22 member 12) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SLC22A12 (solute carrier family 22 member 12) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
SLC22A11 (solute carrier family 22 member 11) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Slc22a12 (solute carrier family 22 member 12)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
SLC22A12 (solute carrier family 22 member 12)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
slc22a6l (solute carrier family 22 member 6, like)
Alliance
DIOPT (OrthoFinder, PANTHER, Roundup)
Drosophila melanogaster (fruit fly):
CG8654
Alliance
DIOPT (Ensembl Compara, OrthoFinder, Roundup)
Drosophila melanogaster (fruit fly):
Orct
Alliance
DIOPT (Ensembl Compara, OrthoFinder, Roundup)
Drosophila melanogaster (fruit fly):
Orct2
Alliance
DIOPT (Ensembl Compara, OrthoFinder, Roundup)
Drosophila melanogaster (fruit fly):
CG6126
Alliance
DIOPT (Ensembl Compara, OrthoFinder, Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 19 6,535,854 - 6,543,070 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 19 6,535,854 - 6,543,070 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 19 6,535,854 - 6,543,006 (-) NCBI mm8 Celera 19 6,408,578 - 6,415,794 (-) NCBI Celera Cytogenetic Map 19 A NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
Familial Renal Hypouricemia due to Tubular Hypersecretion ISO RGD:1323543 8554872 ClinVar Annotator: match by term: Familial renal hypouricemia ClinVar Familial Renal Hypouricemia due to Tubular Hypersecretion ISO RGD:1323543 8554872 ClinVar Annotator: match by term: Familial renal hypouricemia ClinVar PMID:14694169 more ... Familial Renal Hypouricemia due to Tubular Hypersecretion ISO RGD:1323543 8554872 ClinVar Annotator: match by term: Familial renal hypouricemia ClinVar PMID:21148271 Familial Renal Hypouricemia due to Tubular Hypersecretion ISO RGD:1323543 8554872 ClinVar Annotator: match by term: Familial renal hypouricemia ClinVar PMID:24033266 Familial Renal Hypouricemia due to Tubular Hypersecretion ISO RGD:1323543 8554872 ClinVar Annotator: match by term: Familial renal hypouricemia ClinVar PMID:12024214 more ... Familial Renal Hypouricemia due to Tubular Hypersecretion ISO RGD:1323543 8554872 ClinVar Annotator: match by term: Familial renal hypouricemia ClinVar PMID:14694169 , PMID:15634722 Familial Renal Hypouricemia due to Tubular Hypersecretion ISO RGD:1323543 8554872 ClinVar Annotator: match by term: Familial renal hypouricemia ClinVar PMID:18492088 Familial Renal Hypouricemia due to Tubular Hypersecretion ISO RGD:1323543 8554872 ClinVar Annotator: match by term: Familial renal hypouricemia ClinVar PMID:15634722 Familial Renal Hypouricemia due to Tubular Hypersecretion ISO RGD:1323543 8554872 ClinVar Annotator: match by term: Familial renal hypouricemia ClinVar PMID:12024214 malignant glioma ISO RGD:1323543 8554872 ClinVar Annotator: match by term: Ependymoma ClinVar Renal Hypouricemia ISO RGD:1323543 8554872 ClinVar Annotator: match by term: Hereditary renal hypouricemia ClinVar PMID:14694169 more ...
Imported Annotations - CTD
acute kidney failure ISO RGD:1323543 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14655203 Renal Hypouricemia ISO RGD:1323543 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14655203 more ... Imported Annotations - OMIM
Renal Hypouricemia ISO RGD:1323543 7240710 OMIM
1,1-dichloroethene decreases expression EXP 6480464 vinylidene chloride results in decreased expression of SLC22A12 mRNA CTD PMID:26682919 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of SLC22A12 protein CTD PMID:21360409 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SLC22A12 mRNA CTD PMID:26377647 2,4-D multiple interactions EXP 6480464 Potassium promotes the reaction [SLC22A12 protein results in increased uptake of 2, 4-Dichlorophenoxyacetic Acid] CTD PMID:15284287 2-hydroxypropanoic acid multiple interactions ISO RGD:621628 6480464 Lactic Acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:21074513 2-hydroxypropanoic acid multiple interactions EXP 6480464 Lactic Acid affects the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of SLC22A12 mRNA CTD PMID:20188158 6-propyl-2-thiouracil increases expression ISO RGD:621628 6480464 Propylthiouracil results in increased expression of SLC22A12 mRNA CTD PMID:24780913 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases import ISO RGD:1323543 6480464 SLC22A12 protein results in increased import of Uric Acid CTD PMID:20639259 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases uptake ISO RGD:1323543 6480464 SLC22A12 protein results in increased uptake of Uric Acid CTD PMID:14694169 more ... 7,9-dihydro-1H-purine-2,6,8(3H)-trione affects transport ISO RGD:621628 6480464 SLC22A12 protein affects the transport of Uric Acid CTD PMID:21074513 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:621628 6480464 Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid] more ... CTD PMID:21074513 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases export EXP 6480464 SLC22A12 protein results in increased export of Uric Acid CTD PMID:15284287 7,9-dihydro-1H-purine-2,6,8(3H)-trione affects transport EXP 6480464 SLC22A12 protein affects the transport of Uric Acid CTD PMID:14747372 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions EXP 6480464 Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid] more ... CTD PMID:14747372 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO RGD:1323543 6480464 6-hydroxybenzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] more ... CTD PMID:16135657 more ... acrylamide decreases expression ISO RGD:621628 6480464 Acrylamide results in decreased expression of SLC22A12 mRNA CTD PMID:28959563 acrylamide decreases expression EXP 6480464 Acrylamide results in decreased expression of SLC22A12 mRNA CTD PMID:30807115 allopurinol multiple interactions EXP 6480464 Allopurinol inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein] CTD PMID:21909718 , PMID:22865646 allopurinol multiple interactions ISO RGD:621628 6480464 Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA], Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 protein] CTD PMID:19605544 alloxanthine multiple interactions ISO RGD:1323543 6480464 Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol], Uric Acid inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol] CTD PMID:16135657 alloxanthine increases uptake ISO RGD:1323543 6480464 SLC22A12 protein results in increased uptake of Oxypurinol CTD PMID:16135657 ammonium chloride affects expression ISO RGD:621628 6480464 Ammonium Chloride affects the expression of SLC22A12 mRNA CTD PMID:16483693 arsane affects methylation ISO RGD:1323543 6480464 Arsenic affects the methylation of SLC22A12 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1323543 6480464 Arsenic affects the methylation of SLC22A12 gene CTD PMID:25304211 barium(0) multiple interactions EXP 6480464 Barium promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15284287 benzarone multiple interactions ISO RGD:1323543 6480464 benzarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 benzbromarone affects activity ISO RGD:1323543 6480464 Benzbromarone affects the activity of SLC22A12 protein CTD PMID:14694169 benzbromarone decreases activity ISO RGD:1323543 6480464 Benzbromarone results in decreased activity of SLC22A12 protein CTD PMID:20486468 , PMID:21449597 benzbromarone multiple interactions ISO RGD:621628 6480464 Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:21074513 benzbromarone multiple interactions EXP 6480464 Benzbromarone inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 benzbromarone affects response to substance ISO RGD:1323543 6480464 SLC22A12 protein affects the susceptibility to Benzbromarone CTD PMID:18670416 benzbromarone multiple interactions ISO RGD:1323543 6480464 Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Oxypurinol], Benzbromarone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:16135657 , PMID:21272127 benzo[a]pyrene multiple interactions EXP 6480464 Benzo(a)pyrene promotes the reaction [AHR protein binds to SLC22A12 promoter] CTD PMID:19654925 benzylpenicillin multiple interactions EXP 6480464 Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Penicillin G] CTD PMID:15284287 bisphenol A decreases methylation EXP 6480464 bisphenol A results in decreased methylation of SLC22A12 promoter CTD PMID:24433282 bisphenol A decreases expression ISO RGD:621628 6480464 bisphenol A results in decreased expression of SLC22A12 mRNA CTD PMID:25181051 buta-1,3-diene increases expression EXP 6480464 1, 3-butadiene results in increased expression of SLC22A12 mRNA CTD PMID:29038090 cadmium atom increases expression ISO RGD:621628 6480464 Cadmium results in increased expression of SLC22A12 mRNA CTD PMID:17327699 cadmium dichloride increases expression ISO RGD:621628 6480464 Cadmium Chloride results in increased expression of SLC22A12 mRNA CTD PMID:17327699 D-gluconic acid multiple interactions EXP 6480464 gluconic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 decabromodiphenyl ether increases expression ISO RGD:621628 6480464 decabromobiphenyl ether results in increased expression of SLC22A12 mRNA CTD PMID:23914054 dehydroepiandrosterone sulfate multiple interactions EXP 6480464 Potassium promotes the reaction [SLC22A12 protein results in increased uptake of Dehydroepiandrosterone Sulfate] CTD PMID:15284287 dichlorine multiple interactions ISO RGD:1323543 6480464 [Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] more ... CTD PMID:20639259 dichloroacetic acid increases expression EXP 6480464 Dichloroacetic Acid results in increased expression of SLC22A12 mRNA CTD PMID:28962523 diethyl pyrocarbonate multiple interactions EXP 6480464 Diethyl Pyrocarbonate inhibits the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15284287 E3040 multiple interactions ISO RGD:1323543 6480464 E 3040 inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 enalapril multiple interactions ISO RGD:1323543 6480464 Enalapril inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 fructose multiple interactions ISO RGD:621628 6480464 Allopurinol inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA] more ... CTD PMID:19605544 fructose increases expression ISO RGD:621628 6480464 Fructose results in increased expression of SLC22A12 mRNA, Fructose results in increased expression of SLC22A12 protein CTD PMID:19605544 imperatorin decreases expression EXP 6480464 imperatorin results in decreased expression of SLC22A12 mRNA CTD PMID:22173200 imperatorin increases expression EXP 6480464 imperatorin results in increased expression of SLC22A12 protein CTD PMID:22173200 indometacin multiple interactions ISO RGD:1323543 6480464 Indomethacin inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 isoimperatorin decreases expression EXP 6480464 isoimperatorin results in decreased expression of SLC22A12 mRNA CTD PMID:22173200 isoimperatorin increases expression EXP 6480464 isoimperatorin results in increased expression of SLC22A12 protein CTD PMID:22173200 losartan decreases activity ISO RGD:1323543 6480464 Losartan results in decreased activity of SLC22A12 protein CTD PMID:20486468 losartan affects response to substance ISO RGD:1323543 6480464 SLC22A12 protein affects the susceptibility to Losartan CTD PMID:18670416 losartan decreases expression ISO RGD:1323543 6480464 Losartan results in decreased expression of SLC22A12 mRNA CTD PMID:20486468 losartan multiple interactions ISO RGD:1323543 6480464 [Losartan results in decreased activity of SLC22A12 protein] which results in decreased abundance of Uric Acid CTD PMID:18670416 mangiferin decreases expression EXP 6480464 mangiferin results in decreased expression of SLC22A12 mRNA, mangiferin results in decreased expression of SLC22A12 protein CTD PMID:21348301 methylmercury chloride decreases expression EXP 6480464 methylmercuric chloride results in decreased expression of SLC22A12 mRNA CTD PMID:19465457 ochratoxin A decreases expression ISO RGD:621628 6480464 ochratoxin A results in decreased expression of SLC22A12 mRNA CTD PMID:18417182 ouabain multiple interactions EXP 6480464 Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15284287 p-aminohippuric acid multiple interactions EXP 6480464 Barium promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] more ... CTD PMID:15284287 p-aminohippuric acid increases uptake EXP 6480464 SLC22A12 protein results in increased uptake of p-Aminohippuric Acid CTD PMID:15284287 paracetamol increases expression ISO RGD:621628 6480464 Acetaminophen results in increased expression of SLC22A12 mRNA CTD PMID:30723492 perfluorodecanoic acid multiple interactions ISO RGD:1323543 6480464 [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] CTD PMID:20639259 perfluoroheptanoic acid multiple interactions ISO RGD:1323543 6480464 [Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] CTD PMID:20639259 perfluorononanoic acid multiple interactions ISO RGD:1323543 6480464 [Chlorine co-treated with perfluoro-n-nonanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid] CTD PMID:20639259 perfluorooctanoic acid multiple interactions ISO RGD:1323543 6480464 [Chlorine co-treated with perfluorooctanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid], Chlorine inhibits the reaction [SLC22A12 protein results in increased import of perfluorooctanoic acid] CTD PMID:20639259 perfluorooctanoic acid increases import ISO RGD:1323543 6480464 SLC22A12 protein results in increased import of perfluorooctanoic acid CTD PMID:20639259 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of SLC22A12 mRNA CTD PMID:19136022 phenylbutazone multiple interactions ISO RGD:1323543 6480464 Phenylbutazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 pirinixic acid affects expression EXP 6480464 pirinixic acid affects the expression of SLC22A12 mRNA CTD PMID:19136022 Potassium 2,6-dihydroxytriazinecarboxylate increases expression EXP 6480464 potassium oxonate results in increased expression of SLC22A12 mRNA, potassium oxonate results in increased expression of SLC22A12 protein CTD PMID:21909718 more ... Potassium 2,6-dihydroxytriazinecarboxylate multiple interactions EXP 6480464 4-hydroxystilbene inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein] more ... CTD PMID:21909718 more ... potassium atom multiple interactions EXP 6480464 Potassium promotes the reaction [SLC22A12 protein results in increased uptake of 2 more ... CTD PMID:15284287 probenecid multiple interactions EXP 6480464 Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA] more ... CTD PMID:14747372 more ... probenecid affects activity ISO RGD:1323543 6480464 Probenecid affects the activity of SLC22A12 protein CTD PMID:14694169 probenecid multiple interactions ISO RGD:1323543 6480464 Probenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 psoralen decreases expression EXP 6480464 Ficusin results in decreased expression of SLC22A12 protein CTD PMID:22173200 pterostilbene multiple interactions EXP 6480464 pterostilbene inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein] CTD PMID:22865646 pyrazine-2-carboxylic acid multiple interactions ISO RGD:621628 6480464 pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:21074513 pyrazine-2-carboxylic acid multiple interactions EXP 6480464 pyrazinoic acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 pyrazinecarboxamide affects activity ISO RGD:1323543 6480464 Pyrazinamide affects the activity of SLC22A12 protein CTD PMID:14694169 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA], Quercetin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein] CTD PMID:21909718 quercetin multiple interactions ISO RGD:621628 6480464 Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA], Quercetin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein] CTD PMID:19605544 rac-lactic acid multiple interactions EXP 6480464 Lactic Acid affects the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:14747372 rac-lactic acid multiple interactions ISO RGD:621628 6480464 Lactic Acid promotes the reaction [SLC22A12 protein affects the transport of Uric Acid] CTD PMID:21074513 rutin multiple interactions ISO RGD:621628 6480464 Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA], Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein] CTD PMID:19605544 salicylates multiple interactions ISO RGD:1323543 6480464 Salicylates inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 sodium arsenite increases expression ISO RGD:1323543 6480464 sodium arsenite results in increased expression of SLC22A12 mRNA CTD PMID:29301061 stilben-4-ol multiple interactions EXP 6480464 4-hydroxystilbene inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein] CTD PMID:22865646 sulfinpyrazone multiple interactions ISO RGD:1323543 6480464 Sulfinpyrazone inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] CTD PMID:21272127 trans-piceid multiple interactions EXP 6480464 polydatin inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein] CTD PMID:22865646 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of SLC22A12 mRNA CTD PMID:17292431 valproic acid increases methylation ISO RGD:1323543 6480464 Valproic Acid results in increased methylation of SLC22A12 gene CTD PMID:29154799 vancomycin increases expression EXP 6480464 Vancomycin results in increased expression of SLC22A12 mRNA CTD PMID:18930951
Gene-Chemical Interaction Annotations
