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Gene: Twf1 (twinfilin actin binding protein 1) Mus musculus
Symbol: Twf1
Name: twinfilin actin binding protein 1
CRRD ID: 1323556
Description: Exhibits actin monomer binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein tyrosine kinase activity. Involved in barbed-end actin filament capping; positive regulation of cardiac muscle hypertrophy; and sequestering of actin monomers. Localizes to several cellular components, including filopodium; myofibril; and perinuclear region of cytoplasm. Colocalizes with ruffle membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TWF1 (twinfilin actin binding protein 1); INTERACTS WITH 1,2-dimethylhydrazine; beta-carotene; carbon nanotube.
Type: protein-coding
Also known as: A; A6; actin monomer-binding protein; protein tyrosine kinase 9; Ptk; Ptk9; PTK9 protein tyrosine kinase 9; twi; Twinf; twinfilin; twinfilin, actin-binding protein, homolog 1; twinfilin-1
Homo sapiens (human) : TWF1 (twinfilin actin binding protein 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Twf1 (twinfilin actin-binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Twf1 (twinfilin actin binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TWF1 (twinfilin actin binding protein 1)
Canis lupus familiaris (dog) : TWF1 (twinfilin actin binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Twf1 (twinfilin actin binding protein 1)
Sus scrofa (pig) : TWF1 (twinfilin actin binding protein 1)
Chlorocebus sabaeus (African green monkey) : TWF1 (twinfilin actin binding protein 1)
Heterocephalus glaber (naked mole-rat) : Twf1 (twinfilin actin binding protein 1)
more info ...
Related Pseudogenes: Gm4887  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1594,577,951 - 94,589,889 (-)EnsemblGRCm38mm10GRCm38
GRCm381594,577,948 - 94,589,884 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371594,408,379 - 94,420,255 (-)NCBIGRCm37mm9NCBIm37
MGSCv361594,406,128 - 94,418,004 (-)NCBImm8
Celera1596,725,758 - 96,737,654 (-)NCBICelera
Cytogenetic Map15E3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Twf1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323556
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.