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Gene: RNF20 (ring finger protein 20) Homo sapiens
Symbol: RNF20
Name: ring finger protein 20
Description: Exhibits several functions, including p53 binding activity; transcription coactivator activity; and ubiquitin protein ligase binding activity. Involved in several processes, including positive regulation of histone H2B ubiquitination; protein ubiquitination; and regulation of RNA metabolic process. Localizes to HULC complex; nucleolus; and nucleoplasm. Implicated in breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BRE1; BRE1 E3 ubiquitin ligase homolog; BRE1-A; BRE1A; E3 ubiquitin-protein ligase BRE1A; FLJ11189; FLJ20382; hBRE1; homolog of S. cerevisiae BRE1; KIAA2779; MGC129667; MGC129668; nm_rev: NM_019592.5 was updated to version 4 to extend the 5' UTR. No other changes were needed.; ring finger protein 20, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase BRE1A
Mus musculus (house mouse) : Rnf20 (ring finger protein 20)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rnf20 (ring finger protein 20)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rnf20 (ring finger protein 20)
Pan paniscus (bonobo/pygmy chimpanzee) : RNF20 (ring finger protein 20)
Canis lupus familiaris (dog) : RNF20 (ring finger protein 20)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rnf20 (ring finger protein 20)
Sus scrofa (pig) : RNF20 (ring finger protein 20)
Chlorocebus sabaeus (African green monkey) : RNF20 (ring finger protein 20)
Heterocephalus glaber (naked mole-rat) : Rnf20 (ring finger protein 20)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl9101,533,853 - 101,563,344 (+)EnsemblGRCh38hg38GRCh38
GRCh389101,533,853 - 101,563,344 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379104,296,131 - 104,325,626 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369103,335,954 - 103,365,447 (+)NCBINCBI36hg18NCBI36
Build 349101,375,687 - 101,405,180NCBI
Celera974,810,388 - 74,839,881 (+)NCBI
Cytogenetic Map9q31.1NCBI
HuRef973,896,855 - 73,926,373 (+)NCBIHuRef
CHM1_19104,442,536 - 104,472,031 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RNF20
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323649
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.