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Gene: POLE2 (DNA polymerase epsilon 2, accessory subunit) Homo sapiens
Symbol: POLE2
Name: DNA polymerase epsilon 2, accessory subunit
Description: Predicted to contribute to DNA-directed DNA polymerase activity. Predicted to be involved in DNA-dependent DNA replication and error-prone translesion synthesis. Localizes to the epsilon DNA polymerase complex and nuclear body.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA polymerase epsilon subunit 2; DNA polymerase epsilon subunit B; DNA polymerase II subunit 2; DPE2; polymerase (DNA directed), epsilon 2 (p59 subunit); polymerase (DNA directed), epsilon 2, accessory subunit; polymerase (DNA) epsilon 2, accessory subunit
Mus musculus (house mouse) : Pole2 (polymerase (DNA directed), epsilon 2 (p59 subunit))  MGI  Alliance
Rattus norvegicus (Norway rat) : Pole2 (DNA polymerase epsilon 2, accessory subunit)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pole2 (DNA polymerase epsilon 2, accessory subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLE2 (DNA polymerase epsilon 2, accessory subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pole2 (DNA polymerase epsilon 2, accessory subunit)
Sus scrofa (pig) : POLE2 (DNA polymerase epsilon 2, accessory subunit)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1449,643,555 - 49,688,422 (-)Ensembl
GRCh381449,643,552 - 49,688,417 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371450,110,270 - 50,155,098 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361449,180,028 - 49,224,685 (-)NCBINCBI36hg18NCBI36
Build 341449,180,027 - 49,224,685NCBI
Celera1429,970,096 - 30,014,595 (-)NCBI
Cytogenetic Map14q21.3NCBI
HuRef1430,227,158 - 30,272,590 (-)NCBIHuRef
CHM1_11450,049,196 - 50,093,831 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on POLE2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323687
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.