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Gene: NFE2L1 (nuclear factor, erythroid 2 like 1) Homo sapiens
Symbol: NFE2L1
Name: nuclear factor, erythroid 2 like 1
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and regulation of odontoblast differentiation. Localizes to cytosol; integral component of endoplasmic reticulum membrane; and nucleoplasm.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: endoplasmic reticulum membrane sensor NFE2L1; FLJ00380; LCR-F1; locus control region-factor 1; NF-E2-related factor 1; NFE2-related factor 1; NRF1; nuclear factor (erythroid-derived 2)-like 1; nuclear factor erythroid 2-related factor 1; nuclear factor, erythroid 2-like 1; nuclear factor, erythroid derived 2, like 1; TCF-11; TCF11; transcription factor 11 (basic leucine zipper type); transcription factor HBZ17; transcription factor LCR-F1
Mus musculus (house mouse) : Nfe2l1 (nuclear factor, erythroid derived 2,-like 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nfe2l1 (nuclear factor, erythroid 2-like 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfe2l1 (nuclear factor, erythroid 2 like 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NFE2L1 (nuclear factor, erythroid 2 like 1)
Canis lupus familiaris (dog) : NFE2L1 (nuclear factor, erythroid 2 like 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfe2l1 (nuclear factor, erythroid 2 like 1)
Sus scrofa (pig) : NFE2L1 (nuclear factor, erythroid 2 like 1)
Chlorocebus sabaeus (African green monkey) : NFE2L1 (nuclear factor, erythroid 2 like 1)
Heterocephalus glaber (naked mole-rat) : Nfe2l1 (nuclear factor, erythroid 2 like 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: NRF1 (Gene ID: 4899) and NFE2L1 (Gene ID: 4779) share the NRF1 symbol/alias in common. NRF1 is a widely used alternative name for nuclear factor, erythroid 2 like 1 (NFE2L1), which can be confused with the official symbol for nuclear respiratory factor 1 (NRF1). [05 Jul 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1748,048,329 - 48,061,545 (+)EnsemblGRCh38hg38GRCh38
GRCh381748,048,359 - 48,061,545 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371746,125,686 - 46,138,907 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361743,480,745 - 43,493,841 (+)NCBINCBI36hg18NCBI36
Build 341743,480,744 - 43,493,840NCBI
Celera1742,578,502 - 42,591,724 (+)NCBI
Cytogenetic Map17q21.32NCBI
HuRef1741,494,079 - 41,507,301 (+)NCBIHuRef
CHM1_11746,190,680 - 46,203,900 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NFE2L1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323705
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.