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Gene: TREX1 (three prime repair exonuclease 1) Homo sapiens
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Symbol: TREX1
Name: three prime repair exonuclease 1
Description: Exhibits 3'-5' exonuclease activity; MutLalpha complex binding activity; and MutSalpha complex binding activity. Predicted to be involved in several processes, including cellular response to UV; cellular response to oxidative stress; and cellular response to type I interferon. Localizes to cytosol. Implicated in Aicardi-Goutieres syndrome; Chilblain lupus; retinal vasculopathy with cerebral leukodystrophy; and systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 3' repair exonuclease 1; 3'-5' exonuclease TREX1; AGS1; Aicardi-Goutieres syndrome 1; CRV; deoxyribonuclease III; deoxyribonuclease III, dnaQ/mutD-like; DKFZp434J0310; DNase III; DRN3; HERNS; three-prime repair exonuclease 1
Orthologs:
Mus musculus (house mouse) : Trex1 (three prime repair exonuclease 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Trex1 (three prime repair exonuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trex1 (three prime repair exonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TREX1 (three prime repair exonuclease 1)
Canis lupus familiaris (dog) : TREX1 (three prime repair exonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trex1 (three prime repair exonuclease 1)
Sus scrofa (pig) : TREX1 (three prime repair exonuclease 1)
Chlorocebus sabaeus (African green monkey) : TREX1 (three prime repair exonuclease 1)
Heterocephalus glaber (naked mole-rat) : Trex1 (three prime repair exonuclease 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: GeneID 11277 was annotated as a single gene with two non-overlapping coding regions. GeneID 11277 now represents only the downstream coding region encoding three prime repair exonuclease 1. The upstream coding region is represented by geneID 84126. [29 May 2007]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl348,465,811 - 48,467,645 (+)EnsemblGRCh38hg38GRCh38
GRCh38348,465,830 - 48,467,645 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37348,506,919 - 48,509,044 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,482,233 - 48,484,048 (+)NCBINCBI36hg18NCBI36
Build 34348,463,221 - 48,482,058NCBI
Celera348,458,088 - 48,459,903 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef348,560,949 - 48,563,074 (+)NCBIHuRef
CHM1_1348,459,219 - 48,461,344 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - curated
References - uncurated

Genomics

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Position Markers
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Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TREX1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323748
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.