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Gene: STK4 (serine/threonine kinase 4) Homo sapiens
Symbol: STK4
Name: serine/threonine kinase 4
Description: Exhibits several functions, including ATP binding activity; magnesium ion binding activity; and protein homodimerization activity. Involved in several processes, including hippo signaling; protein phosphorylation; and protein stabilization. Localizes to the cytosol; nuclear body; and protein-containing complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)); DKFZp686A2068; kinase responsive to stress 2; KRS2; mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; MST-1; MST1; serine/threonine-protein kinase 4; serine/threonine-protein kinase Krs-2; STE20-like kinase MST1; TIIAC; yeast Ste20-like; YSK3
Mus musculus (house mouse) : Stk4 (serine/threonine kinase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Stk4 (serine/threonine kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Stk4 (serine/threonine kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : STK4 (serine/threonine kinase 4)
Canis lupus familiaris (dog) : STK4 (serine/threonine kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Stk4 (serine/threonine kinase 4)
Sus scrofa (pig) : STK4 (serine/threonine kinase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: MST1 (Gene ID: 4485) and STK4 (Gene ID: 6789) share the MST1 symbol/alias in common. MST1 is a widely used alternative name for serine/threonine kinase 4 (STK4), which can be confused with the official symbol for macrophage stimulating 1 (MST1). [01 Jun 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382044,966,470 - 45,080,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372043,595,120 - 43,708,600 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362043,028,534 - 43,142,008 (+)NCBINCBI36hg18NCBI36
Build 342043,028,533 - 43,142,005NCBI
Celera2040,303,755 - 40,417,237 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2040,336,825 - 40,450,492 (+)NCBIHuRef
CHM1_12043,497,895 - 43,611,365 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on STK4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323808
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.