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Gene: AKT1S1 (AKT1 substrate 1) Homo sapiens
Symbol: AKT1S1
Name: AKT1 substrate 1
Description: Involved in negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. Localizes to cytosol. Colocalizes with TORC1 complex.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 40 kDa proline-rich AKT substrate; AKT1 substrate 1 (proline rich); AKT1 substrate 1 (proline-rich); Lobe; MGC2865; PRAS40; proline-rich Akt substrate, 40 kDa; proline-rich AKT1 substrate 1
Mus musculus (house mouse) : Akt1s1 (AKT1 substrate 1 (proline-rich))  MGI  Alliance
Rattus norvegicus (Norway rat) : Akt1s1 (AKT1 substrate 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akt1s1 (AKT1 substrate 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AKT1S1 (AKT1 substrate 1)
Canis lupus familiaris (dog) : AKT1S1 (AKT1 substrate 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akt1s1 (AKT1 substrate 1)
Sus scrofa (pig) : AKT1S1 (AKT1 substrate 1)
Chlorocebus sabaeus (African green monkey) : AKT1S1 (AKT1 substrate 1)
Heterocephalus glaber (naked mole-rat) : Akt1s1 (AKT1 substrate 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1949,869,033 - 49,878,459 (-)EnsemblGRCh38hg38GRCh38
GRCh381949,869,033 - 49,878,356 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371950,372,290 - 50,381,613 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,064,108 - 55,072,456 (-)NCBINCBI36hg18NCBI36
Build 341955,064,108 - 55,072,342NCBI
Celera1947,241,806 - 47,250,153 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1946,748,627 - 46,757,949 (-)NCBIHuRef
CHM1_11950,374,126 - 50,383,449 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AKT1S1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1323832
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.