Gene: Sdhaf2 (succinate dehydrogenase complex assembly factor 2) Mus musculus
Analyze
Symbol:
Sdhaf2
Name:
succinate dehydrogenase complex assembly factor 2
Description:
Involved in negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial to mesenchymal transition; and protein dephosphorylation. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in paraganglioma. Orthologous to human SDHAF2 (succinate dehydrogenase complex assembly factor 2); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; benzo[a]pyrene; cadmium atom.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
0610038F07Rik; AA407634; AW049997; MGC61338; SDH assembly factor 2; succinate dehydrogenase assembly factor 2, mitochondrial; succinate dehydrogenase subunit 5, mitochondrial
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
SDHAF2 (succinate dehydrogenase complex assembly factor 2) HGNC
HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Sdhaf2 (succinate dehydrogenase complex assembly factor 2) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB
Chinchilla lanigera (long-tailed chinchilla):
Sdhaf2 (succinate dehydrogenase complex assembly factor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
SDHAF2 (succinate dehydrogenase complex assembly factor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
SDHAF2 (succinate dehydrogenase complex assembly factor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Sdhaf2 (succinate dehydrogenase complex assembly factor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
SDHAF2 (succinate dehydrogenase complex assembly factor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Sdhaf2 (succinate dehydrogenase complex assembly factor 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Homo sapiens (human):
SDHAF2 (succinate dehydrogenase complex assembly factor 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
sdhaf2 (succinate dehydrogenase complex assembly factor 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
CG12895
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
SDH5
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
Y57A10A.29
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Drosophila melanogaster (fruit fly):
CG14757
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 19 10,500,512 - 10,525,209 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 19 10,575,002 - 10,599,699 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 19 10,568,685 - 10,592,254 (-) NCBI mm8 Celera 19 11,196,361 - 11,220,981 (-) NCBI Celera Cytogenetic Map 19 A NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Hereditary Neoplastic Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:28492532 Hereditary Neoplastic Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:21224366 more ... Hereditary Neoplastic Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:20071235 , PMID:28492532 Hereditary Neoplastic Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:22241717 , PMID:28492532 Hereditary Neoplastic Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:22703879 , PMID:28492532 Hereditary Neoplastic Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:22241717 more ... Hereditary Neoplastic Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:19628817 more ... Hereditary Neoplastic Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary cancer-predisposing syndrome ClinVar PMID:22703879 more ... Hereditary Neoplastic Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary ClinVar PMID:23175444 Hereditary Neoplastic Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Neoplastic Syndromes, Hereditary ClinVar Hereditary Paraganglioma-Pheochromocytoma Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma Syndromes ClinVar PMID:28492532 Hereditary Paraganglioma-Pheochromocytoma Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma Syndromes ClinVar PMID:21224366 more ... Hereditary Paraganglioma-Pheochromocytoma Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma Syndromes ClinVar PMID:20071235 , PMID:28492532 Hereditary Paraganglioma-Pheochromocytoma Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma Syndromes ClinVar PMID:24033266 , PMID:28492532 Hereditary Paraganglioma-Pheochromocytoma Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma Syndromes ClinVar PMID:22241717 , PMID:28492532 Hereditary Paraganglioma-Pheochromocytoma Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma Syndromes ClinVar PMID:22703879 , PMID:28492532 Hereditary Paraganglioma-Pheochromocytoma Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma Syndromes ClinVar PMID:22241717 more ... Hereditary Paraganglioma-Pheochromocytoma Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma Syndromes ClinVar PMID:19628817 more ... Hereditary Paraganglioma-Pheochromocytoma Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma Syndromes ClinVar PMID:22241717 more ... Hereditary Paraganglioma-Pheochromocytoma Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma Syndromes ClinVar PMID:22703879 more ... Hereditary Paraganglioma-Pheochromocytoma Syndromes ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Hereditary Paraganglioma-Pheochromocytoma Syndromes ClinVar PMID:25741868 , PMID:28492532 Paragangliomas 2 ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Paragangliomas 2 ClinVar PMID:19628817 more ... pheochromocytoma ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Pheochromocytoma ClinVar pheochromocytoma ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Pheochromocytoma ClinVar PMID:22703879 more ... pheochromocytoma ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Pheochromocytoma ClinVar PMID:28492532 pheochromocytoma ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Pheochromocytoma ClinVar PMID:25741868 , PMID:28492532 pheochromocytoma ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Pheochromocytoma ClinVar PMID:20071235 , PMID:24712571 Tumor Predisposition Syndrome ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Tumor predisposition syndrome ClinVar Tumor Predisposition Syndrome ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Tumor susceptibility linked to germline BAP1 mutations ClinVar PMID:22241717 , PMID:28492532 Tumor Predisposition Syndrome ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Tumor susceptibility linked to germline BAP1 mutations ClinVar PMID:28492532 Tumor Predisposition Syndrome ISO RGD:1606278 8554872 ClinVar Annotator: match by term: Tumor predisposition syndrome ClinVar PMID:23175444
Imported Annotations - CTD
Gene-Chemical Interaction Annotations
