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Gene: Nsmce2 (NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase) Mus musculus
Symbol: Nsmce2
Name: NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
Description: Predicted to have SUMO transferase activity. Predicted to be involved in DNA recombination; cellular senescence; and positive regulation of mitotic sister chromatid segregation. Predicted to localize to the PML body; Smc5-Smc6 complex; and chromosome, telomeric region. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Is expressed in brain; spermatocyte; and testis. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; carbon nanotube.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110014D18Rik; AI661537; E3 SUMO-protein ligase NSE2; E3 SUMO-protein transferase NSE2; MMS21 homolog; non-SMC element 2 homolog (MMS21, S. cerevisiae); non-structural maintenance of chromosomes element 2 homolog
Related Pseudogenes: Gm19019   Gm5203  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1559,374,247 - 59,601,684 (+)EnsemblGRCm38mm10GRCm38
GRCm381559,374,198 - 59,601,684 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371559,205,753 - 59,433,239 (+)NCBIGRCm37mm9NCBIm37
MGSCv361559,203,928 - 59,431,364 (+)NCBImm8
Celera1560,905,217 - 61,133,508 (+)NCBICelera
Cytogenetic Map15D1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Nsmce2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1331905
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.