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Gene: Bace1 (beta-site APP cleaving enzyme 1) Mus musculus
Symbol: Bace1
Name: beta-site APP cleaving enzyme 1
Description: Exhibits aspartic-type endopeptidase activity. Involved in several processes, including amyloid precursor protein catabolic process; amyloid-beta metabolic process; and membrane protein ectodomain proteolysis. Localizes to several cellular components, including the endosome; hippocampal mossy fiber to CA3 synapse; and trans-Golgi network. Used to study schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in brain; liver; and metanephros. Orthologous to human BACE1 (beta-secretase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: APP beta-secretase; asp 2; ASP2; aspartyl protease 2; Bace; beta-secretase 1; beta-site amyloid precursor protein cleaving enzyme 1; C76936; memapsin-2; membrane-associated aspartic protease 2
Homo sapiens (human) : BACE1 (beta-secretase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Bace1 (beta-secretase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bace1 (beta-secretase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BACE1 (beta-secretase 1)
Canis lupus familiaris (dog) : BACE1 (beta-secretase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bace1 (beta-secretase 1)
Sus scrofa (pig) : BACE1 (beta-secretase 1)
Chlorocebus sabaeus (African green monkey) : BACE1 (beta-secretase 1)
Heterocephalus glaber (naked mole-rat) : Bace1 (beta-secretase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl945,838,580 - 45,864,399 (+)EnsemblGRCm38mm10GRCm38
GRCm38945,838,545 - 45,862,484 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37945,646,612 - 45,670,567 (+)NCBIGRCm37mm9NCBIm37
MGSCv36945,589,578 - 45,613,436 (+)NCBImm8
Celera943,121,304 - 43,145,259 (+)NCBICelera
Cytogenetic Map9 A5.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Bace1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1332039
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.