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Gene: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4) Mus musculus
Symbol: Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
Description: Exhibits eukaryotic translation initiation factor 2alpha kinase activity and tRNA binding activity. Involved in several processes, including generation of neurons; learning or memory; and regulation of translational initiation. Localizes to intracellular and polysome. Is expressed in brain; oocyte; and ovary. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2610011M03; eIF-2-alpha kinase GCN2; eukaryotic translation initiation factor 2-alpha kinase 4; GCN; GCN2; GCN2 eIF2alpha kinase; GCN2-like protein; MGCN2
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl2118,388,618 - 118,475,234 (+)EnsemblGRCm38mm10GRCm38
GRCm382118,388,583 - 118,475,234 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372118,214,353 - 118,300,970 (+)NCBIGRCm37mm9NCBIm37
MGSCv362118,080,058 - 118,166,674 (+)NCBImm8
Celera2119,539,566 - 119,626,375 (+)NCBICelera
Cytogenetic Map2E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Eif2ak4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1332170
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.