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Gene: Egln1 (egl-9 family hypoxia-inducible factor 1) Mus musculus
Symbol: Egln1
Name: egl-9 family hypoxia-inducible factor 1
Description: Predicted to have enzyme binding activity; ferrous iron binding activity; and peptidyl-proline 4-dioxygenase activity. Involved in several processes, including heart morphogenesis; labyrinthine layer development; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Localizes to the glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Is expressed in brain; genitourinary system; and trunk. Orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1); PARTICIPATES IN hypoxia inducible factor pathway; renal cell carcinoma pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI503754; C1orf12; egl nine homolog 1; Hif-p4h-2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; hypoxia-inducible factor prolyl hydroxylase 2; ORF13; Phd2; prolyl hydroxylase domain-containing protein 2; SM-20
Homo sapiens (human) : EGLN1 (egl-9 family hypoxia inducible factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Egln1 (egl-9 family hypoxia-inducible factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Egln1 (egl-9 family hypoxia inducible factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : EGLN1 (egl-9 family hypoxia inducible factor 1)
Canis lupus familiaris (dog) : EGLN1 (egl-9 family hypoxia inducible factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Egln1 (egl-9 family hypoxia inducible factor 1)
Sus scrofa (pig) : EGLN1 (egl-9 family hypoxia inducible factor 1)
Chlorocebus sabaeus (green monkey) : EGLN1 (egl-9 family hypoxia inducible factor 1)
Heterocephalus glaber (naked mole-rat) : Egln1 (egl-9 family hypoxia inducible factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl8124,908,587 - 124,949,324 (-)Ensembl
GRCm388124,908,587 - 124,949,254 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv378127,432,487 - 127,473,154 (-)NCBIGRCm37mm9NCBIm37
MGSCv368127,794,676 - 127,801,870 (-)NCBImm8
Celera8129,217,254 - 129,257,497 (-)NCBICelera
Cytogenetic Map8E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Egln1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1332220
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.