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Gene: Duox2 (dual oxidase 2) Mus musculus
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Symbol: Duox2
Name: dual oxidase 2
Description: Predicted to have NAD(P)H oxidase activity; calcium ion binding activity; and superoxide-generating NADPH oxidase activity. Involved in several processes, including animal organ development; growth; and thyroid hormone metabolic process. Predicted to localize to several cellular components, including the NADPH oxidase complex; cell leading edge; and cell surface. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism. Is expressed in placenta and thyroid gland. Orthologous to human DUOX2 (dual oxidase 2); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH 17beta-estradiol; thyroxine; 3,7-dihydropurine-6-thione (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A430065P05Rik; LNOX2; NOXEF2; P138-TOX; THOX2
Orthologs:
Homo sapiens (human) : DUOX2 (dual oxidase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Duox2 (dual oxidase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Duox2 (dual oxidase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : DUOX2 (dual oxidase 2)
Canis lupus familiaris (dog) : DUOX2 (dual oxidase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Duox2 (dual oxidase 2)
Sus scrofa (pig) : DUOX2 (dual oxidase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382122,279,246 - 122,298,740 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372122,106,173 - 122,123,901 (-)NCBIGRCm37mm9NCBIm37
MGSCv362121,971,878 - 121,989,606 (-)NCBImm8
Celera2123,430,543 - 123,448,297 (-)NCBICelera
Cytogenetic Map2 E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
 
More on Duox2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1332300
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.