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Gene: Dync1h1 (dynein cytoplasmic 1 heavy chain 1) Mus musculus
Symbol: Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Description: Exhibits dynein light intermediate chain binding activity. Involved in cytoplasmic mRNA processing body assembly; positive regulation of cold-induced thermogenesis; and stress granule assembly. Localizes to the cytoplasm and filopodium. Used to study Charcot-Marie-Tooth disease axonal type 2O. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant non-syndromic intellectual disability 13; and spinal muscular atrophy. Is expressed in several structures, including early conceptus; nervous system; neural retina; placenta; and spleen. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1); PARTICIPATES IN mitochondria transport pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9930018I23Rik; AI894280; cytoplasmic dynein 1 heavy chain 1; cytoplasmic dynein heavy chain 1; DHC1; DHC1a; Dnchc1; DNCL; Dnec1; Dnecl; dynein heavy chain, cytosolic; dynein heavy chain, retrograde transport; dynein, cytoplasmic, heavy chain 1; legs at odd angle; Loa; MAP1C; mKIAA0325; P22; sprawling; Swl
Homo sapiens (human) : DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dync1h1 (dynein cytoplasmic 1 heavy chain 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dync1h1 (dynein cytoplasmic 1 heavy chain 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Canis lupus familiaris (dog) : DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dync1h1 (dynein cytoplasmic 1 heavy chain 1)
Sus scrofa (pig) : DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Chlorocebus sabaeus (green monkey) : DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Heterocephalus glaber (naked mole-rat) : Dync1h1 (dynein cytoplasmic 1 heavy chain 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl12110,601,452 - 110,666,945 (+)Ensembl
GRCm3812110,601,395 - 110,666,944 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712111,839,605 - 111,905,154 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612111,049,261 - 111,114,731 (+)NCBImm8
Celera12111,791,744 - 111,857,176 (+)NCBICelera
Cytogenetic Map12 F1NCBI
cM Map1260.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dync1h1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1332334
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.