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Gene: Dync1h1 (dynein cytoplasmic 1 heavy chain 1) Mus musculus
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Symbol: Dync1h1
Name: dynein cytoplasmic 1 heavy chain 1
Description: Exhibits dynein light intermediate chain binding activity. Involved in cytoplasmic mRNA processing body assembly; positive regulation of cold-induced thermogenesis; and stress granule assembly. Localizes to the cytoplasm and filopodium. Used to study Charcot-Marie-Tooth disease axonal type 2O. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2O; autosomal dominant non-syndromic intellectual disability 13; and spinal muscular atrophy. Is expressed in several structures, including early conceptus; nervous system; neural retina; placenta; and spleen. Orthologous to human DYNC1H1 (dynein cytoplasmic 1 heavy chain 1); PARTICIPATES IN mitochondria transport pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9930018I23Rik; AI894280; cytoplasmic dynein 1 heavy chain 1; cytoplasmic dynein heavy chain 1; DHC1; DHC1a; Dnchc1; DNCL; Dnec1; Dnecl; dynein heavy chain, cytosolic; dynein heavy chain, retrograde transport; dynein, cytoplasmic, heavy chain 1; legs at odd angle; Loa; MAP1C; mKIAA0325; P22; sprawling; Swl
Orthologs:
Homo sapiens (human) : DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dync1h1 (dynein cytoplasmic 1 heavy chain 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dync1h1 (dynein cytoplasmic 1 heavy chain 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Canis lupus familiaris (dog) : DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dync1h1 (dynein cytoplasmic 1 heavy chain 1)
Sus scrofa (pig) : DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Chlorocebus sabaeus (green monkey) : DYNC1H1 (dynein cytoplasmic 1 heavy chain 1)
Heterocephalus glaber (naked mole-rat) : Dync1h1 (dynein cytoplasmic 1 heavy chain 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl12110,601,452 - 110,666,945 (+)Ensembl
GRCm3812110,601,395 - 110,666,944 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712111,839,605 - 111,905,154 (+)NCBIGRCm37mm9NCBIm37
MGSCv3612111,049,261 - 111,114,731 (+)NCBImm8
Celera12111,791,744 - 111,857,176 (+)NCBICelera
Cytogenetic Map12 F1NCBI
cM Map1260.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Dync1h1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1332334
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.