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Gene: Inpp5e (inositol polyphosphate-5-phosphatase E) Mus musculus
Symbol: Inpp5e
Name: inositol polyphosphate-5-phosphatase E
Description: Exhibits phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in inositol phosphate dephosphorylation; negative regulation of protein localization to cilium; and phosphatidylinositol dephosphorylation. Localizes to Golgi membrane and axoneme. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 1. Orthologous to human INPP5E (inositol polyphosphate-5-phosphatase E); PARTICIPATES IN phosphoinositide metabolic pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 1,2-dichloroethane; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1200002L24Rik; 72 kDa inositol polyphosphate 5-phosphatase; 72kDa; inositol polyphosphate-5-phosphatase, 72 kDa; mKIAA0123; phosphatidylinositol 4,5-bisphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type IV; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase
Homo sapiens (human) : INPP5E (inositol polyphosphate-5-phosphatase E)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Inpp5e (inositol polyphosphate-5-phosphatase E)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Inpp5e (inositol polyphosphate-5-phosphatase E)
Pan paniscus (bonobo/pygmy chimpanzee) : INPP5E (inositol polyphosphate-5-phosphatase E)
Canis lupus familiaris (dog) : INPP5E (inositol polyphosphate-5-phosphatase E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Inpp5e (inositol polyphosphate-5-phosphatase E)
Sus scrofa (pig) : INPP5E (inositol polyphosphate-5-phosphatase E)
Chlorocebus sabaeus (African green monkey) : INPP5E (inositol polyphosphate-5-phosphatase E)
Heterocephalus glaber (naked mole-rat) : Inpp5e (inositol polyphosphate-5-phosphatase E)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl226,396,249 - 26,409,203 (-)EnsemblGRCm38mm10GRCm38
GRCm38226,396,249 - 26,409,244 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37226,251,769 - 26,264,708 (-)NCBIGRCm37mm9NCBIm37
MGSCv36226,218,258 - 26,231,197 (-)NCBImm8
Celera226,113,925 - 26,126,902 (-)NCBICelera
Cytogenetic Map2A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Inpp5e
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1332343
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.