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Gene: Fcgr2b (Fc receptor, IgG, low affinity IIb) Mus musculus
Symbol: Fcgr2b
Name: Fc receptor, IgG, low affinity IIb
Description: Exhibits IgG binding activity. Involved in several processes, including negative regulation of immune effector process; regulation of cellular response to stress; and regulation of phagocytosis. Localizes to several cellular components, including cell body; dendritic spine; and external side of plasma membrane. Is expressed in liver and spleen. Used to study malaria and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in several diseases, including arthritis (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc fragment of IgG receptor IIb); PARTICIPATES IN clathrin-mediated endocytosis pathway; B cell receptor signaling pathway; measles pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI528646; CD32; F630109E10Rik; fc gamma receptor IIB; Fc gamma RIIB; fc-gamma RII; Fc-gamma-RII; fc-gamma-RIIB; Fc[g]RII; FcgammaRIIB; Fcgr2; Fcgr2a; FcgRII; Fcr-2; Fcr-3; fcRII; igG Fc receptor II beta; low affinity immunoglobulin gamma Fc region receptor II; low affinity immunoglobulin gamma Fc region receptor II-b; Ly-17; Ly-m20; LyM-1; lymphocyte antigen 17
Homo sapiens (human) : FCGR2B (Fc fragment of IgG receptor IIb)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Fcgr2b (Fc fragment of IgG receptor IIb)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fcgr2b (Fc fragment of IgG receptor IIb)
Pan paniscus (bonobo/pygmy chimpanzee) : FCGR2B (Fc fragment of IgG receptor IIb)
Canis lupus familiaris (dog) : LOC100856270 (low affinity immunoglobulin gamma Fc region receptor II)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fcgr2b (Fc fragment of IgG receptor IIb)
Sus scrofa (pig) : FCGR2B (Fc fragment of IgG, low affinity IIb, receptor (CD32))
Chlorocebus sabaeus (African green monkey) : FCGR2B (Fc fragment of IgG receptor IIb)
Heterocephalus glaber (naked mole-rat) : Fcgr2b (Fc fragment of IgG receptor IIb)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1170,958,617 - 170,976,547 (-)EnsemblGRCm38mm10GRCm38
GRCm381170,960,558 - 170,976,071 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371172,890,689 - 172,906,202 (-)NCBIGRCm37mm9NCBIm37
MGSCv361172,797,258 - 172,812,708 (-)NCBImm8
Celera1173,410,273 - 173,425,760 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map178.02NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Fcgr2b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1332447
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.