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Gene: Tph2 (tryptophan hydroxylase 2) Mus musculus
Symbol: Tph2
Name: tryptophan hydroxylase 2
Description: Exhibits tryptophan 5-monooxygenase activity. Predicted to be involved in serotonin biosynthetic process from tryptophan. Localizes to the neuron projection. Used to study endogenous depression. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; major depressive disorder; and panic disorder. Is expressed in several structures, including central nervous system; early conceptus; enteric nervous system; germ cell of ovary; and retina. Orthologous to human TPH2 (tryptophan hydroxylase 2); PARTICIPATES IN tryptophan metabolic pathway; INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU043594; MGC159133; neuronal tryptophan hydroxylase; Ntph; tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2
Homo sapiens (human) : TPH2 (tryptophan hydroxylase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tph2 (tryptophan hydroxylase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tph2 (tryptophan hydroxylase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TPH2 (tryptophan hydroxylase 2)
Canis lupus familiaris (dog) : TPH2 (tryptophan hydroxylase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tph2 (tryptophan hydroxylase 2)
Sus scrofa (pig) : TPH2 (tryptophan hydroxylase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3810115,078,641 - 115,185,022 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3710114,515,697 - 114,622,078 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610114,482,751 - 114,589,132 (-)NCBImm8
Celera10117,006,698 - 117,113,837 (-)NCBICelera
Cytogenetic Map10 D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tph2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1332580
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.