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Gene: Tph2 (tryptophan hydroxylase 2) Mus musculus
Symbol: Tph2
Name: tryptophan hydroxylase 2
CRRD ID: 1332580
Description: Exhibits tryptophan 5-monooxygenase activity. Predicted to be involved in serotonin biosynthetic process from tryptophan. Localizes to neuron projection. Is expressed in several structures, including central nervous system; early conceptus; enteric nervous system; germ cell of ovary; and retina. Used to study endogenous depression. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; major depressive disorder; and panic disorder. Orthologous to human TPH2 (tryptophan hydroxylase 2); PARTICIPATES IN tryptophan metabolic pathway; INTERACTS WITH (S)-nicotine; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AU043594; MGC159133; neuronal tryptophan hydroxylase; Ntph; tryptophan 5-hydroxylase 2; tryptophan 5-monooxygenase 2
Homo sapiens (human) : TPH2 (tryptophan hydroxylase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tph2 (tryptophan hydroxylase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tph2 (tryptophan hydroxylase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TPH2 (tryptophan hydroxylase 2)
Canis lupus familiaris (dog) : TPH2 (tryptophan hydroxylase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tph2 (tryptophan hydroxylase 2)
Sus scrofa (pig) : TPH2 (tryptophan hydroxylase 2)
Chlorocebus sabaeus (African green monkey) : TPH2 (tryptophan hydroxylase 2)
Heterocephalus glaber (naked mole-rat) : Tph2 (tryptophan hydroxylase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910114,914,546 - 115,020,927 (-)NCBI
GRCm3810115,078,641 - 115,185,022 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10115,078,641 - 115,185,022 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710114,515,697 - 114,622,078 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610114,482,751 - 114,589,132 (-)NCBImm8
Celera10117,006,698 - 117,113,837 (-)NCBICelera
Cytogenetic Map10D2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tph2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1332580
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.