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Gene: PIR (pirin) Homo sapiens
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Symbol: PIR
Name: pirin
Description: This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: pirin (iron-binding nuclear protein); probable quercetin 2,3-dioxygenase PIR; probable quercetinase
Orthologs:
Mus musculus (house mouse) : Pir (pirin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pir (pirin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pir (pirin)
Pan paniscus (bonobo/pygmy chimpanzee) : PIR (pirin)
Canis lupus familiaris (dog) : PIR (pirin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pir (pirin)
Sus scrofa (pig) : PIR (pirin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X15,384,799 - 15,493,588 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,402,921 - 15,511,711 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,312,842 - 15,421,385 (-)NCBINCBI36hg18NCBI36
Build 34X15,162,582 - 15,271,113NCBI
CeleraX19,518,436 - 19,626,837 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,159,639 - 13,268,835 (-)NCBIHuRef
CHM1_1X15,433,843 - 15,542,647 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PIR
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342511
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.