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Gene: PIR (pirin) Homo sapiens
Symbol: PIR
Name: pirin
Description: This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: pirin (iron-binding nuclear protein); probable quercetin 2,3-dioxygenase PIR; probable quercetinase
Mus musculus (house mouse) : Pir (pirin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pir (pirin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pir (pirin)
Pan paniscus (bonobo/pygmy chimpanzee) : PIR (pirin)
Canis lupus familiaris (dog) : PIR (pirin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pir (pirin)
Sus scrofa (pig) : PIR (pirin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X15,384,799 - 15,493,588 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X15,402,921 - 15,511,711 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X15,312,842 - 15,421,385 (-)NCBINCBI36hg18NCBI36
Build 34X15,162,582 - 15,271,113NCBI
CeleraX19,518,436 - 19,626,837 (-)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX13,159,639 - 13,268,835 (-)NCBIHuRef
CHM1_1X15,433,843 - 15,542,647 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PIR
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342511
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.