Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: GRHL2 (grainyhead like transcription factor 2) Homo sapiens
Analyze
Symbol: GRHL2
Name: grainyhead like transcription factor 2
CRRD ID: 1342517
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including bicellular tight junction assembly; negative regulation of keratinocyte differentiation; and regulation of nucleobase-containing compound metabolic process. Localizes to cell-cell junction and nucleoplasm. Implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BOM; brother of mammalian grainyhead; DFNA28; ECTDS; FLJ11172; FLJ13782; grainyhead-like 2; grainyhead-like protein 2 homolog; grainyhead-like transcription factor 2; MGC149294; MGC149295; PPCD4; TFCP2L3; transcription factor CP2-like 3
Orthologs:
Mus musculus (house mouse) : Grhl2 (grainyhead like transcription factor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Grhl2 (grainyhead-like transcription factor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Grhl2 (grainyhead like transcription factor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GRHL2 (grainyhead like transcription factor 2)
Canis lupus familiaris (dog) : GRHL2 (grainyhead like transcription factor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Grhl2 (grainyhead like transcription factor 2)
Sus scrofa (pig) : GRHL2 (grainyhead like transcription factor 2)
Chlorocebus sabaeus (African green monkey) : GRHL2 (grainyhead like transcription factor 2)
Heterocephalus glaber (naked mole-rat) : Grhl2 (grainyhead like transcription factor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8101,492,439 - 101,669,726 (+)EnsemblGRCh38hg38GRCh38
GRCh388101,492,439 - 101,678,104 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378102,504,668 - 102,681,954 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368102,574,162 - 102,750,995 (+)NCBINCBI36hg18NCBI36
Build 348102,574,161 - 102,750,995NCBI
Celera898,689,599 - 98,866,864 (+)NCBI
Cytogenetic Map8q22.3NCBI
HuRef897,702,727 - 97,879,982 (+)NCBIHuRef
CHM1_18102,544,909 - 102,722,208 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GRHL2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342517
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-27
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.