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Gene: TEK (TEK receptor tyrosine kinase) Homo sapiens
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Symbol: TEK
Name: TEK receptor tyrosine kinase
Description: Exhibits protein tyrosine kinase activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and regulation of angiogenesis. Localizes to several cellular components, including the basal plasma membrane; centriolar satellite; and microvillus. Colocalizes with the actin filament and stress fiber. Implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. Biomarker of coronary artery disease and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: angiopoietin-1 receptor; CD202B; endothelial tyrosine kinase; GLC3E; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; TEK tyrosine kinase, endothelial; TIE-2; TIE2; tunica interna endothelial cell kinase; tyrosine kinase with Ig and EGF homology domains-2; tyrosine-protein kinase receptor TEK; tyrosine-protein kinase receptor TIE-2; VMCM; VMCM1
Orthologs:
Mus musculus (house mouse) : Tek (TEK receptor tyrosine kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tek (TEK receptor tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tek (TEK receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : TEK (TEK receptor tyrosine kinase)
Canis lupus familiaris (dog) : TEK (TEK receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tek (TEK receptor tyrosine kinase)
Sus scrofa (pig) : TEK (TEK receptor tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38927,109,141 - 27,230,178 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37927,109,147 - 27,230,172 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36927,099,286 - 27,220,172 (+)NCBINCBI36hg18NCBI36
Build 34927,099,440 - 27,220,164NCBI
Celera927,037,320 - 27,158,328 (+)NCBI
Cytogenetic Map9p21.2NCBI
HuRef927,061,676 - 27,182,725 (+)NCBIHuRef
CHM1_1927,108,917 - 27,229,958 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TEK
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342531
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.