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Gene: TEK (TEK receptor tyrosine kinase) Homo sapiens
Symbol: TEK
Name: TEK receptor tyrosine kinase
Description: Exhibits protein tyrosine kinase activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and regulation of angiogenesis. Localizes to several cellular components, including the basal plasma membrane; centriolar satellite; and microvillus. Colocalizes with the actin filament and stress fiber. Implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. Biomarker of coronary artery disease and pulmonary hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: angiopoietin-1 receptor; CD202B; endothelial tyrosine kinase; GLC3E; hTIE2; p140 TEK; soluble TIE2 variant 1; soluble TIE2 variant 2; TEK tyrosine kinase, endothelial; TIE-2; TIE2; tunica interna endothelial cell kinase; tyrosine kinase with Ig and EGF homology domains-2; tyrosine-protein kinase receptor TEK; tyrosine-protein kinase receptor TIE-2; VMCM; VMCM1
Mus musculus (house mouse) : Tek (TEK receptor tyrosine kinase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tek (TEK receptor tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tek (TEK receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : TEK (TEK receptor tyrosine kinase)
Canis lupus familiaris (dog) : TEK (TEK receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tek (TEK receptor tyrosine kinase)
Sus scrofa (pig) : TEK (TEK receptor tyrosine kinase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38927,109,141 - 27,230,178 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37927,109,147 - 27,230,172 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36927,099,286 - 27,220,172 (+)NCBINCBI36hg18NCBI36
Build 34927,099,440 - 27,220,164NCBI
Celera927,037,320 - 27,158,328 (+)NCBI
Cytogenetic Map9p21.2NCBI
HuRef927,061,676 - 27,182,725 (+)NCBIHuRef
CHM1_1927,108,917 - 27,229,958 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TEK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342531
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.