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Gene: CLCN4 (chloride voltage-gated channel 4) Homo sapiens
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Symbol: CLCN4
Name: chloride voltage-gated channel 4
Description: The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chloride channel 4; chloride channel protein 4; chloride channel, voltage-sensitive 4; chloride transporter ClC-4; ClC-4; ClC-4A; CLC4; H(+)/Cl(-) exchange transporter 4; mental retardation, X-linked 15; mental retardation, X-linked 49; MGC163150; MRX15; MRX49; MRXSRC
Orthologs:
Mus musculus (house mouse) : Clcn4 (chloride channel, voltage-sensitive 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clcn4 (chloride voltage-gated channel 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clcn4 (chloride voltage-gated channel 4)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCN4 (chloride voltage-gated channel 4)
Canis lupus familiaris (dog) : CLCN4 (chloride voltage-gated channel 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcn4 (chloride voltage-gated channel 4)
Sus scrofa (pig) : CLCN4 (chloride voltage-gated channel 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X10,156,945 - 10,237,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X10,124,985 - 10,205,700 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X10,084,985 - 10,165,700 (+)NCBINCBI36hg18NCBI36
Build 34X9,934,772 - 10,013,256NCBI
CeleraX14,296,240 - 14,376,955 (+)NCBI
Cytogenetic MapXp22.2NCBI
HuRefX7,954,825 - 8,038,622 (+)NCBIHuRef
CHM1_1X10,155,417 - 10,236,107 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - uncurated

Genomics

Comparative Map Data
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miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CLCN4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342594
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.