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Gene: FHL1 (four and a half LIM domains 1) Homo sapiens
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Symbol: FHL1
Name: four and a half LIM domains 1
Description: This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. Expression of these family members occurs in a cell- and tissue-specific mode and these proteins are involved in many cellular processes. Mutations in this gene have been found in patients with Emery-Dreifuss muscular dystrophy. Multiple alternately spliced transcript variants which encode different protein isoforms have been described.[provided by RefSeq, Nov 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FCMSU; FHL-1; FHL1A; FHL1B; FLH1A; four and a half LIM domains protein 1; four-and-a-half Lin11, Isl-1 and Mec-3 domains 1; KYOT; LIM protein SLIMMER; MGC111107; RBMX1A; RBMX1B; skeletal muscle LIM-protein 1; skeletal muscle LIM-protein1; SLIM; SLIM-1; SLIM1; SLIMMER; XMPMA
Orthologs:
Mus musculus (house mouse) : Fhl1 (four and a half LIM domains 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fhl1 (four and a half LIM domains 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fhl1 (four and a half LIM domains 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FHL1 (four and a half LIM domains 1)
Canis lupus familiaris (dog) : FHL1 (four and a half LIM domains 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fhl1 (four and a half LIM domains 1)
Sus scrofa (pig) : FHL1 (four and a half LIM domains 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X136,146,702 - 136,211,359 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X135,228,861 - 135,293,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X135,057,346 - 135,121,176 (+)NCBINCBI36hg18NCBI36
Build 34X134,955,199 - 135,019,028NCBI
CeleraX135,591,521 - 135,656,168 (+)NCBI
Cytogenetic MapXq26.3NCBI
HuRefX124,502,588 - 124,565,831 (+)NCBIHuRef
CHM1_1X135,139,444 - 135,204,087 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on FHL1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342641
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.