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Gene: KLF4 (Kruppel like factor 4) Homo sapiens
Symbol: KLF4
Name: Kruppel like factor 4
CRRD ID: 1342656
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription factor binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; regulation of cellular biosynthetic process; and regulation of sprouting angiogenesis. Localizes to nuclear chromatin and nucleoplasm. Implicated in hepatocellular carcinoma. Biomarker of hepatocellular carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: endothelial Kruppel-like zinc finger protein; epithelial zinc finger protein EZF; EZF; GKLF; gut Kruppel-like factor; gut-enriched krueppel-like factor; Krueppel-like factor 4; Kruppel-like factor 4 (gut)
Mus musculus (house mouse) : Klf4 (Kruppel-like factor 4 (gut))  MGI  Alliance
Rattus norvegicus (Norway rat) : Klf4 (Kruppel like factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Klf4 (Kruppel like factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : KLF4 (Kruppel like factor 4)
Canis lupus familiaris (dog) : KLF4 (Kruppel like factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Klf4 (Kruppel like factor 4)
Sus scrofa (pig) : KLF4 (Kruppel like factor 4)
Chlorocebus sabaeus (African green monkey) : KLF4 (Kruppel like factor 4)
Heterocephalus glaber (naked mole-rat) : Klf4 (Kruppel like factor 4)
more info ...
Related Pseudogenes: KLF4P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl9107,484,852 - 107,490,482 (-)EnsemblGRCh38hg38GRCh38
GRCh389107,484,852 - 107,489,769 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379110,247,133 - 110,252,047 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369109,286,956 - 109,291,576 (-)NCBINCBI36hg18NCBI36
Build 349107,326,689 - 107,331,310NCBI
Celera980,749,144 - 80,754,056 (-)NCBI
Cytogenetic Map9q31.2NCBI
HuRef979,848,720 - 79,853,633 (-)NCBIHuRef
CHM1_19110,393,822 - 110,398,611 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on KLF4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342656
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.