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Gene: CUL4B (cullin 4B) Homo sapiens
Symbol: CUL4B
Name: cullin 4B
Description: This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CUL-4B; cullin-4B; DKFZp686F1470; KIAA0695; MRXHF2; MRXS15; MRXSC; SFM2
Mus musculus (house mouse) : Cul4b (cullin 4B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cul4b (cullin 4B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cul4b (cullin 4B)
Pan paniscus (bonobo/pygmy chimpanzee) : CUL4B (cullin 4B)
Canis lupus familiaris (dog) : CUL4B (cullin 4B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cul4b (cullin 4B)
Sus scrofa (pig) : CUL4B (cullin 4B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X120,524,589 - 120,575,829 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X119,658,444 - 119,709,684 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X119,542,472 - 119,593,712 (-)NCBINCBI36hg18NCBI36
Build 34X119,442,379 - 119,491,531NCBI
CeleraX120,122,944 - 120,174,184 (-)NCBI
Cytogenetic MapXq24NCBI
HuRefX109,109,003 - 109,160,669 (-)NCBIHuRef
CHM1_1X119,570,086 - 119,621,321 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on CUL4B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342683
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.