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Gene: CUL4B (cullin 4B) Homo sapiens
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Symbol: CUL4B
Name: cullin 4B
Description: This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CUL-4B; cullin-4B; DKFZp686F1470; KIAA0695; MRXHF2; MRXS15; MRXSC; SFM2
Orthologs:
Mus musculus (house mouse) : Cul4b (cullin 4B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cul4b (cullin 4B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cul4b (cullin 4B)
Pan paniscus (bonobo/pygmy chimpanzee) : CUL4B (cullin 4B)
Canis lupus familiaris (dog) : CUL4B (cullin 4B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cul4b (cullin 4B)
Sus scrofa (pig) : CUL4B (cullin 4B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X120,524,589 - 120,575,829 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X119,658,444 - 119,709,684 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X119,542,472 - 119,593,712 (-)NCBINCBI36hg18NCBI36
Build 34X119,442,379 - 119,491,531NCBI
CeleraX120,122,944 - 120,174,184 (-)NCBI
Cytogenetic MapXq24NCBI
HuRefX109,109,003 - 109,160,669 (-)NCBIHuRef
CHM1_1X119,570,086 - 119,621,321 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on CUL4B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342683
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-08-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.