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Gene: DCT (dopachrome tautomerase) Homo sapiens
Symbol: DCT
Name: dopachrome tautomerase
Description: Predicted to have dopachrome isomerase activity. Predicted to be involved in developmental pigmentation; generation of neurons; and melanin biosynthetic process from tyrosine. Localizes to the intracellular membrane-bounded organelle and plasma membrane; PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH (+)-artemisinic acid; 2,3,7,8-tetrachlorodibenzodioxine; 5-fluorouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dopachrome delta-isomerase; dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2); DT; L-dopachrome Delta-isomerase; L-dopachrome isomerase; L-dopachrome tautomerase; TRP-2; TRP2; tyrosinase related protein-2; tyrosinase-related protein 2; tyrosine-related protein 2; TYRP2
Mus musculus (house mouse) : Dct (dopachrome tautomerase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dct (dopachrome tautomerase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dct (dopachrome tautomerase)
Pan paniscus (bonobo/pygmy chimpanzee) : DCT (dopachrome tautomerase)
Canis lupus familiaris (dog) : DCT (dopachrome tautomerase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dct (dopachrome tautomerase)
Sus scrofa (pig) : DCT (dopachrome tautomerase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381394,436,811 - 94,549,406 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371395,091,835 - 95,131,936 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361393,889,836 - 93,929,924 (-)NCBINCBI36hg18NCBI36
Build 341393,889,839 - 93,929,924NCBI
Celera1375,940,079 - 75,980,144 (-)NCBI
Cytogenetic Map13q32.1NCBI
HuRef1375,688,784 - 75,728,851 (-)NCBIHuRef
CHM1_11395,059,070 - 95,171,100 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DCT
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342702
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.