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Gene: SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin) Homo sapiens
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Symbol: SPG7
Name: SPG7 matrix AAA peptidase subunit, paraplegin
Description: Exhibits metalloendopeptidase activity. Involved in mitochondrial outer membrane permeabilization involved in programmed cell death. Localizes to the mitochondrial permeability transition pore complex. Implicated in hereditary spastic paraplegia 7.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAR; cell adhesion regulator; cell matrix adhesion regulator; CMAR; FLJ37308; MGC126331; MGC126332; paraplegin; paraplegin, isoform 1; PGN; spastic paraplegia 7 (pure and complicated autosomal recessive); spastic paraplegia 7 protein; spastic paraplegia 7, paraplegin (pure and complicated autosomal recessive); SPG5C; SPG7, paraplegin matrix AAA peptidase subunit
Orthologs:
Mus musculus (house mouse) : Spg7 (SPG7, paraplegin matrix AAA peptidase subunit)  MGI  Alliance
Rattus norvegicus (Norway rat) : Spg7 (SPG7 matrix AAA peptidase subunit, paraplegin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spg7 (SPG7 matrix AAA peptidase subunit, paraplegin)
Pan paniscus (bonobo/pygmy chimpanzee) : SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)
Canis lupus familiaris (dog) : SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spg7 (SPG7 matrix AAA peptidase subunit, paraplegin)
Sus scrofa (pig) : SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)
Chlorocebus sabaeus (green monkey) : SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin)
Heterocephalus glaber (naked mole-rat) : Spg7 (SPG7 matrix AAA peptidase subunit, paraplegin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1689,490,719 - 89,557,768 (+)Ensembl
GRCh381689,508,379 - 89,557,768 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371689,574,802 - 89,624,174 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361688,102,306 - 88,151,675 (+)NCBINCBI36hg18NCBI36
Build 341688,102,305 - 88,151,674NCBI
Celera1674,638,312 - 74,687,680 (+)NCBI
Cytogenetic Map16q24.3NCBI
HuRef1675,270,019 - 75,319,275 (+)NCBIHuRef
CHM1_11690,986,076 - 91,035,447 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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RNA-SEQ Expression

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Nomenclature History
 
More on SPG7
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342736
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.