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Gene: LAT2 (linker for activation of T cells family member 2) Homo sapiens
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Symbol: LAT2
Name: linker for activation of T cells family member 2
Description: Exhibits SH2 domain binding activity. Involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Localizes to the membrane raft and plasma membrane. Implicated in Williams-Beuren syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HSPC046; LAB; linker for activation of B cells; linker for activation of B-cells; linker for activation of T cells family, member 2; linker for activation of T cells, transmembrane adaptor 2; linker for activation of T-cells family member 2; membrane-associated adapter molecule; non-T cell activation linker; non-T-cell activation linker; NTAL; WBSCR15; WBSCR5; williams-Beuren syndrome chromosomal region 15 protein; williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosome region 15; WSCR5
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: LAT2 (Gene ID: 7462) and SLC7A8 (Gene ID: 23428) share the LAT2 symbol/alias in common. LAT2 is sometimes used as an alternative name for solute carrier family 7 member 8 (SLC7A8), which can be confused with the official symbol for linker for activation of T cells family member 2 (LAT2). [05 Jul 2018]
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38774,210,006 - 74,229,834 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37773,624,087 - 73,644,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,262,023 - 73,282,100 (+)NCBINCBI36hg18NCBI36
Build 34773,068,925 - 73,088,808NCBI
Celera769,103,651 - 69,123,730 (+)NCBI
Cytogenetic Map7q11.23NCBI
HuRef769,505,694 - 69,525,599 (+)NCBIHuRef
CHM1_1773,769,175 - 73,789,226 (+)NCBICHM1_1
CRA_TCAGchr7v2772,957,159 - 72,977,236 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on LAT2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342914
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.