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Gene: LAT2 (linker for activation of T cells family member 2) Homo sapiens
Symbol: LAT2
Name: linker for activation of T cells family member 2
Description: Exhibits SH2 domain binding activity. Involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Localizes to the membrane raft and plasma membrane. Implicated in Williams-Beuren syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HSPC046; LAB; linker for activation of B cells; linker for activation of B-cells; linker for activation of T cells family, member 2; linker for activation of T cells, transmembrane adaptor 2; linker for activation of T-cells family member 2; membrane-associated adapter molecule; non-T cell activation linker; non-T-cell activation linker; NTAL; WBSCR15; WBSCR5; williams-Beuren syndrome chromosomal region 15 protein; williams-Beuren syndrome chromosomal region 5 protein; Williams-Beuren syndrome chromosome region 15; WSCR5
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: LAT2 (Gene ID: 7462) and SLC7A8 (Gene ID: 23428) share the LAT2 symbol/alias in common. LAT2 is sometimes used as an alternative name for solute carrier family 7 member 8 (SLC7A8), which can be confused with the official symbol for linker for activation of T cells family member 2 (LAT2). [05 Jul 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38774,210,006 - 74,229,834 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37773,624,087 - 73,644,164 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36773,262,023 - 73,282,100 (+)NCBINCBI36hg18NCBI36
Build 34773,068,925 - 73,088,808NCBI
Celera769,103,651 - 69,123,730 (+)NCBI
Cytogenetic Map7q11.23NCBI
HuRef769,505,694 - 69,525,599 (+)NCBIHuRef
CHM1_1773,769,175 - 73,789,226 (+)NCBICHM1_1
CRA_TCAGchr7v2772,957,159 - 72,977,236 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on LAT2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1342914
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.